Literature DB >> 1704856

Identification of the protein and cDNA of the cardiac Na+/H+ exchanger.

L Fliegel1, C Sardet, J Pouyssegur, A Barr.   

Abstract

We examined the myocardial form of the Na+/H+ exchanger. A partial length cDNA clone was isolated from a rabbit cardiac library and it encoded for a Na+/H+ exchange protein. In comparison with the human Na+/H+ exchanger, the sequence of the 5' end of the cDNA was highly conserved, much more than the 3' region, while the deduced amino acid sequence was also highly conserved. To further characterize the myocardial Na+/H+ exchange protein, we examined Western blots of isolated sarcolemma with antibody produced against a fusion protein of the Na+/H+ exchanger. The antibodies reacted with a sarcolemma protein of 50 kDa and with a protein of 70 kDa. The results show that the rabbit myocardium does possess a Na+/H+ exchanger protein homologous to the known human Na+/H+ exchanger.

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Year:  1991        PMID： 1704856     DOI： 10.1016/0014-5793(91)80241-t

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  18 in total

Review 1.  Functional and cellular regulation of the myocardial Na+/H+ exchanger.

Authors:  L Fliegel
Journal:  J Thromb Thrombolysis       Date:  1999-07       Impact factor: 2.300

2.  Phosphorylation of the C-terminal domain of the Na+/H+ exchanger by Ca2+/calmodulin-dependent protein kinase II.

Authors:  L Fliegel; M P Walsh; D Singh; C Wong; A Barr
Journal:  Biochem J       Date:  1992-02-15       Impact factor: 3.857

Review 3.  Ion transporters in brain tumors.

Authors:  Damin Cong; Wen Zhu; John S Kuo; Shaoshan Hu; Dandan Sun
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

Review 4.  Structure/function studies of the epithelial isoforms of the mammalian Na+/H+ exchanger gene family.

Authors:  M Tse; S Levine; C Yun; S Brant; L T Counillon; J Pouyssegur; M Donowitz
Journal:  J Membr Biol       Date:  1993-08       Impact factor: 1.843

Review 5.  The Na+/H+ exchanger: an update on structure, regulation and cardiac physiology.

Authors:  L Fliegel; O Fröhlich
Journal:  Biochem J       Date:  1993-12-01       Impact factor: 3.857

6.  Characterization of the placental brush border membrane Na+/H+ exchanger: identification of thiol-dependent transitions in apparent molecular size.

Authors:  L Fliegel; R S Haworth; J R Dyck
Journal:  Biochem J       Date:  1993-01-01       Impact factor: 3.857

7.  Glucose metabolism, H+ production and Na+/H+-exchanger mRNA levels in ischemic hearts from diabetic rats.

Authors:  J R Dyck; G D Lopaschuk
Journal:  Mol Cell Biochem       Date:  1998-03       Impact factor: 3.396

Review 8.  Role of Genetic Mutations of the Na+/H+ Exchanger Isoform 1, in Human Disease and Protein Targeting and Activity.

Authors:  Larry Fliegel
Journal:  Mol Cell Biochem       Date:  2020-11-17       Impact factor: 3.396

9.  Overexpression of the NHE1 isoform of the Na(+)/H (+) exchanger causes elevated apoptosis in isolated cardiomyocytes after hypoxia/reoxygenation challenge.

Authors:  Pratap Karki; Larry Fliegel
Journal:  Mol Cell Biochem       Date:  2009-12-01       Impact factor: 3.396

10.  Cloning and analysis of the human myocardial Na+/H+ exchanger.

Authors:  L Fliegel; J R Dyck; H Wang; C Fong; R S Haworth
Journal:  Mol Cell Biochem       Date:  1993-08-25       Impact factor: 3.396
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