C L Liu1, S T Fan, C M Lo, W K Tso, C M Lam, J Wong. 1. Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong, Hong Kong, China. clliu@hkucc.hku.hk
Abstract
BACKGROUND: The aim of the present study was to assess whether an aggressive surgical approach in the management of patients with hilar cholangiocarcinoma was associated with improved operative and survival outcomes. METHODS: Eighty-two patients with hilar cholangiocarcinoma treated between 1989 and 1998 (period 1), and 60 patients treated between 1999 and 2004 (period 2), were evaluated. Modifications to management in period 2 primarily included percutaneous biliary drainage instead of endoscopic drainage for relief of obstructive jaundice, preoperative right portal vein embolization before right-sided hepatectomy, routine total caudate lobectomy and radical lymphadenectomy during surgical resection of the tumour. RESULTS: The surgical resection rate was significantly higher in period 2 than in period 1 (45 versus 16 per cent; P < 0.001). All patients in period 2 underwent major hepatectomy with concomitant caudate lobectomy. The operative morbidity and hospital mortality rates decreased significantly in period 2 compared with period 1, with significantly better survival outcomes. In multivariate analysis, resection of the tumour in period 2 and operative blood loss of 1.5 litres or less were the significant independent factors associated with improved survival. CONCLUSION: An aggressive surgical approach was associated with improved operative and survival outcomes for patients with hilar cholangiocarcinoma.
BACKGROUND: The aim of the present study was to assess whether an aggressive surgical approach in the management of patients with hilar cholangiocarcinoma was associated with improved operative and survival outcomes. METHODS: Eighty-two patients with hilar cholangiocarcinoma treated between 1989 and 1998 (period 1), and 60 patients treated between 1999 and 2004 (period 2), were evaluated. Modifications to management in period 2 primarily included percutaneous biliary drainage instead of endoscopic drainage for relief of obstructive jaundice, preoperative right portal vein embolization before right-sided hepatectomy, routine total caudate lobectomy and radical lymphadenectomy during surgical resection of the tumour. RESULTS: The surgical resection rate was significantly higher in period 2 than in period 1 (45 versus 16 per cent; P < 0.001). All patients in period 2 underwent major hepatectomy with concomitant caudate lobectomy. The operative morbidity and hospital mortality rates decreased significantly in period 2 compared with period 1, with significantly better survival outcomes. In multivariate analysis, resection of the tumour in period 2 and operative blood loss of 1.5 litres or less were the significant independent factors associated with improved survival. CONCLUSION: An aggressive surgical approach was associated with improved operative and survival outcomes for patients with hilar cholangiocarcinoma.
Authors: T Hyodo; S Kumano; F Kushihata; M Okada; M Hirata; T Tsuda; Y Takada; T Mochizuki; T Murakami Journal: Br J Radiol Date: 2012-03-14 Impact factor: 3.039
Authors: Mohamed Abd ElWahab; Ayman El Nakeeb; Ehab El Hanafy; Ahmad M Sultan; Ahmed Elghawalby; Waleed Askr; Mahmoud Ali; Mohamed Abd El Gawad; Tarek Salah Journal: World J Gastrointest Surg Date: 2016-06-27
Authors: Min Soo Cho; Sung Hoon Kim; Seung Woo Park; Jin Hong Lim; Gi Hong Choi; Joon Seong Park; Jae Bock Chung; Kyung Sik Kim Journal: J Gastrointest Surg Date: 2012-07-14 Impact factor: 3.452
Authors: Alfred Wei-Chieh Kow; Choi Dong Wook; Sun Choon Song; Woo Seok Kim; Min Jung Kim; Hyo Jun Park; Jin Soek Heo; Seong Ho Choi Journal: World J Surg Date: 2012-05 Impact factor: 3.352
Authors: Timothy J Kennedy; Adam Yopp; Yilin Qin; Binsheng Zhao; Pingzhen Guo; Fan Liu; Larry H Schwartz; Peter Allen; Michael D'Angelica; Yuman Fong; Ronald P DeMatteo; Leslie H Blumgart; William R Jarnagin Journal: HPB (Oxford) Date: 2009-08 Impact factor: 3.647