Cooperative binding and multiple recognition by bridged bis(beta-cyclodextrin)s with functional linkers.

Possessing two beta-cyclodextrin cavities in close vicinity and a functional linker with good structural variety in a single molecule, bridged bis(beta-cyclodextrin)s can significantly enhance the original binding ability and molecular selectivity of native beta-cyclodextrin and thus be successfully utilized in drug carriers, solubilizers, catalysis, photochemical materials, etc. This Account describes recent developments in the intramolecular cooperative binding and multiple recognition of bridged bis(beta-cyclodextrin)s with functional linkers in solution, as well as their molecular assembly behaviors through the intermolecular cooperative binding. It also gives a description of unique properties and wide applications of bis(beta-cyclodextrin)s and their assemblies.