STUDY OBJECTIVES: To clarify the possibility of a hereditary predisposition to lung cancer, we investigated the association between a family history of lung cancer and subsequent risk of lung cancer in a large-scale, population-based cohort study. DESIGN: We investigated 102,255 middle-aged and older Japanese subjects (48,834 men and 53,421 women) with 13-year follow-up. A total of 791 cases of lung cancer were newly diagnosed during the follow-up period. RESULTS: A family history of lung cancer in a first-degree relative was associated with a significantly increased risk of lung cancer (hazard ratio [HR], 1.95; 95% confidence interval [CI], 1.31 to 2.88). The association was stronger in women than in men (HR, 2.65; 95% CI, 1.40 to 5.01 and HR, 1.69; 95% CI, 1.03 to 2.78, respectively), and in never-smokers than in current smokers (HR, 2.48; 95% CI, 1.27 to 4.84 and HR, 1.73; 95% CI, 0.99 to 3.00, respectively). In addition, family history was more strongly associated with the risk of squamous cell carcinoma than with other histologic types (HR, 2.79; 95% CI, 1.37 to 5.68), while no clear increase in risk was observed in adenocarcinoma and small cell carcinoma. A family history of overall cancer was not associated with an increased risk of lung cancer. CONCLUSIONS: These results suggest that those with a family history of lung cancer are more likely to acquire lung cancer themselves.
STUDY OBJECTIVES: To clarify the possibility of a hereditary predisposition to lung cancer, we investigated the association between a family history of lung cancer and subsequent risk of lung cancer in a large-scale, population-based cohort study. DESIGN: We investigated 102,255 middle-aged and older Japanese subjects (48,834 men and 53,421 women) with 13-year follow-up. A total of 791 cases of lung cancer were newly diagnosed during the follow-up period. RESULTS: A family history of lung cancer in a first-degree relative was associated with a significantly increased risk of lung cancer (hazard ratio [HR], 1.95; 95% confidence interval [CI], 1.31 to 2.88). The association was stronger in women than in men (HR, 2.65; 95% CI, 1.40 to 5.01 and HR, 1.69; 95% CI, 1.03 to 2.78, respectively), and in never-smokers than in current smokers (HR, 2.48; 95% CI, 1.27 to 4.84 and HR, 1.73; 95% CI, 0.99 to 3.00, respectively). In addition, family history was more strongly associated with the risk of squamous cell carcinoma than with other histologic types (HR, 2.79; 95% CI, 1.37 to 5.68), while no clear increase in risk was observed in adenocarcinoma and small cell carcinoma. A family history of overall cancer was not associated with an increased risk of lung cancer. CONCLUSIONS: These results suggest that those with a family history of lung cancer are more likely to acquire lung cancer themselves.
Authors: Michele L Coté; Mei Liu; Stefano Bonassi; Monica Neri; Ann G Schwartz; David C Christiani; Margaret R Spitz; Joshua E Muscat; Gad Rennert; Katja K Aben; Angeline S Andrew; Vladimir Bencko; Heike Bickeböller; Paolo Boffetta; Paul Brennan; Hermann Brenner; Eric J Duell; Eleonora Fabianova; John K Field; Lenka Foretova; Søren Friis; Curtis C Harris; Ivana Holcatova; Yun-Chul Hong; Dolores Isla; Vladimir Janout; Lambertus A Kiemeney; Chikako Kiyohara; Qing Lan; Philip Lazarus; Jolanta Lissowska; Loic Le Marchand; Dana Mates; Keitaro Matsuo; Jose I Mayordomo; John R McLaughlin; Hal Morgenstern; Heiko Müeller; Irene Orlow; Bernard J Park; Mila Pinchev; Olaide Y Raji; Hedy S Rennert; Peter Rudnai; Adeline Seow; Isabelle Stucker; Neonila Szeszenia-Dabrowska; M Dawn Teare; Anne Tjønnelan; Donatella Ugolini; Henricus F M van der Heijden; Erich Wichmann; John K Wiencke; Penella J Woll; Ping Yang; David Zaridze; Zuo-Feng Zhang; Carol J Etzel; Rayjean J Hung Journal: Eur J Cancer Date: 2012-03-19 Impact factor: 9.162
Authors: Ying Gao; Alisa M Goldstein; Dario Consonni; Angela C Pesatori; Sholom Wacholder; Margaret A Tucker; Neil E Caporaso; Lynn Goldin; Maria Teresa Landi Journal: Int J Cancer Date: 2009-07-01 Impact factor: 7.396
Authors: Charles M Rudin; Erika Avila-Tang; Curtis C Harris; James G Herman; Fred R Hirsch; William Pao; Ann G Schwartz; Kirsi H Vahakangas; Jonathan M Samet Journal: Clin Cancer Res Date: 2009-09-15 Impact factor: 12.531