Po-Chung Cheng1, Yun-Chung Cheng1. 1. 1 Department of Internal Medicine, 2 Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan.
Abstract
BACKGROUND: Lung cancer is a leading cause of cancer deaths in the world. Cigarette smoking remains a prominent risk factor, but lung cancer incidence has been increasing in never smokers. Genetic abnormalities including epidermal growth factor receptor (EGFR) mutations predominate in never smoking lung cancer patients. Furthermore, familial aggregations of patients with these mutations reflect heritable susceptibility to lung cancer. The correlation between familial cancer history and EGFR mutations in never smokers with lung cancer requires investigation. METHODS: This was a retrospective case-control study that evaluated the prevalence of EGFR mutations in lung cancer patients with familial cancer history. Never smokers with lung cancer treated at a hospital in Taiwan between April 2012 and May 2014 were evaluated. Inclusion criteria were never smokers with non-small cell lung cancer (NSCLC). Exclusion criteria involved patients without records of familial cancer history or tumor genotype. RESULTS: This study included 246 never smokers with lung cancer. The study population mainly involved never smoking women with a mean age of 60 years, and the predominant tumor histology was adenocarcinoma. Lung cancer patients with familial cancer history had an increased prevalence of EGFR mutations compared to patients without family history [odds ratio (OR): 5.9; 95% confidence interval (CI): 3.3-10.6; P<0.001]. Specifically, 57 out of 85 cancer patients (67%) with familial cancer history had these mutations, while 41 out of 161 patients (25%) without family history harbored mutations. Subgroup analysis also revealed that patients with familial lung cancer history had stronger association with EGFR mutations (OR: 7.5; 95% CI: 3.4-16.3; P<0.001) compared to patients with family history of non-pulmonary cancers (OR: 5.0; 95% CI: 2.5-10.0; P<0.001). CONCLUSIONS: The study demonstrated an increased prevalence of EGFR mutations in Taiwanese never smoking lung cancer patients with familial cancer history. Moreover, a sizable proportion of never smoking cancer patients harbored these mutations. These observations have implications for the treatment of lung cancer in never smokers.
BACKGROUND:Lung cancer is a leading cause of cancer deaths in the world. Cigarette smoking remains a prominent risk factor, but lung cancer incidence has been increasing in never smokers. Genetic abnormalities including epidermal growth factor receptor (EGFR) mutations predominate in never smoking lung cancerpatients. Furthermore, familial aggregations of patients with these mutations reflect heritable susceptibility to lung cancer. The correlation between familial cancer history and EGFR mutations in never smokers with lung cancer requires investigation. METHODS: This was a retrospective case-control study that evaluated the prevalence of EGFR mutations in lung cancerpatients with familial cancer history. Never smokers with lung cancer treated at a hospital in Taiwan between April 2012 and May 2014 were evaluated. Inclusion criteria were never smokers with non-small cell lung cancer (NSCLC). Exclusion criteria involved patients without records of familial cancer history or tumor genotype. RESULTS: This study included 246 never smokers with lung cancer. The study population mainly involved never smoking women with a mean age of 60 years, and the predominant tumor histology was adenocarcinoma. Lung cancerpatients with familial cancer history had an increased prevalence of EGFR mutations compared to patients without family history [odds ratio (OR): 5.9; 95% confidence interval (CI): 3.3-10.6; P<0.001]. Specifically, 57 out of 85 cancerpatients (67%) with familial cancer history had these mutations, while 41 out of 161 patients (25%) without family history harbored mutations. Subgroup analysis also revealed that patients with familial lung cancer history had stronger association with EGFR mutations (OR: 7.5; 95% CI: 3.4-16.3; P<0.001) compared to patients with family history of non-pulmonary cancers (OR: 5.0; 95% CI: 2.5-10.0; P<0.001). CONCLUSIONS: The study demonstrated an increased prevalence of EGFR mutations in Taiwanese never smoking lung cancerpatients with familial cancer history. Moreover, a sizable proportion of never smoking cancerpatients harbored these mutations. These observations have implications for the treatment of lung cancer in never smokers.
Authors: Jolanta Lissowska; Lenka Foretova; Joanna Dabek; David Zaridze; Neonila Szeszenia-Dabrowska; Peter Rudnai; Eleonora Fabianova; Adrian Cassidy; Dana Mates; Vladimir Bencko; Vladimir Janout; Rayjean J Hung; Paul Brennan; Paolo Boffetta Journal: Cancer Causes Control Date: 2010-03-21 Impact factor: 2.506
Authors: Seo Yun Kim; Hye-Ryoun Kim; Cheol Hyeon Kim; Jae Soo Koh; Hee Jong Baek; Chang-Min Choi; Joon Seon Song; Jae Cheol Lee; Im Ii Na Journal: Ann Thorac Med Date: 2017 Jan-Mar Impact factor: 2.219