Literature DB >> 1703520

Expression of transforming growth factor-beta 1 mRNA in human hepatocellular carcinoma.

N Ito1, S Kawata, S Tamura, K Takaishi, I Yabuuchi, Y Matsuda, M Nishioka, S Tarui.   

Abstract

We investigated the expression of transforming growth factor beta 1 (TGF-beta 1) mRNA in tumor tissues surgically removed from ten patients with hepatocellular carcinoma (HCC). All HCC tissues expressed TGF-beta 1 mRNA at different levels, indicating the presence of activated transcription of TGF-beta 1 gene in human HCC tissues in vivo. The level of TGF-beta 1 mRNA expression showed no relationship to main tumor size of plasma alpha-fetoprotein level. Some HCC tissues presenting a relatively low grade of histological differentiation showed the highest levels of TGF-beta 1 mRNA expression.

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Year:  1990        PMID： 1703520      PMCID： PMC5918001          DOI： 10.1111/j.1349-7006.1990.tb02678.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  26 in total

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Authors:  S Nakajima-Iijima; H Hamada; P Reddy; T Kakunaga
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2.  Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts.

Authors:  R A Ignotz; J Massagué
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

3.  Effects of transforming growth factor-beta on matrix synthesis by chick growth plate chondrocytes.

Authors:  R J O'Keefe; J E Puzas; J S Brand; R N Rosier
Journal:  Endocrinology       Date:  1988-06       Impact factor: 4.736

Review 4.  Peptide growth factors are multifunctional.

Authors:  M B Sporn; A B Roberts
Journal:  Nature       Date:  1988-03-17       Impact factor: 49.962

5.  Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta.

Authors:  S M Seyedin; P R Segarini; D M Rosen; A Y Thompson; H Bentz; J Graycar
Journal:  J Biol Chem       Date:  1987-02-15       Impact factor: 5.157

6.  Expression of TGF-beta and procollagen type I and type III in human gastric carcinomas.

Authors:  K Yoshida; H Yokozaki; M Niimoto; H Ito; M Ito; E Tahara
Journal:  Int J Cancer       Date:  1989-09-15       Impact factor: 7.396

7.  Changes in expression of albumin and alpha-fetoprotein genes during rat liver development and neoplasia.

Authors:  J M Sala-Trepat; J Dever; T D Sargent; K Thomas; S Sell; J Bonner
Journal:  Biochemistry       Date:  1979-05-29       Impact factor: 3.162

8.  Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2.

Authors:  J L Graycar; D A Miller; B A Arrick; R M Lyons; H L Moses; R Derynck
Journal:  Mol Endocrinol       Date:  1989-12

9.  Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

Authors:  T Masui; L M Wakefield; J F Lechner; M A LaVeck; M B Sporn; C C Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

10.  Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

Authors:  J H Kehrl; A B Roberts; L M Wakefield; S Jakowlew; M B Sporn; A S Fauci
Journal:  J Immunol       Date:  1986-12-15       Impact factor: 5.422
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  6 in total

1.  Induced differentiation of hepatocellular carcinoma by natural products.

Authors:  Xiong-Zhi Wu; Guang-Ru Xie
Journal:  Afr J Tradit Complement Altern Med       Date:  2008-06-18

2.  Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma.

Authors:  S R Sue; R S Chari; F M Kong; J J Mills; R L Fine; R L Jirtle; W C Meyers
Journal:  Ann Surg       Date:  1995-08       Impact factor: 12.969

3.  Elevated urinary transforming growth factor-beta1 level as a tumour marker and predictor of poor survival in cirrhotic hepatocellular carcinoma.

Authors:  J F Tsai; J E Jeng; L Y Chuang; M L Yang; M S Ho; W Y Chang; M Y Hsieh; Z Y Lin; J H Tsai
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

4.  Clinical evaluation of urinary transforming growth factor-beta1 and serum alpha-fetoprotein as tumour markers of hepatocellular carcinoma.

Authors:  J F Tsai; J E Jeng; L Y Chuang; M L Yang; M S Ho; W Y Chang; M Y Hsieh; Z Y Lin; J H Tsai
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

Review 5.  Serum and tissue markers in hepatocellular carcinoma and cholangiocarcinoma: clinical and prognostic implications.

Authors:  Massimiliano Berretta; Carla Cavaliere; Lara Alessandrini; Brigida Stanzione; Gaetano Facchini; Luca Balestreri; Tiziana Perin; Vincenzo Canzonieri
Journal:  Oncotarget       Date:  2017-02-21

6.  Elevated levels of plasma transforming growth factor-beta in patients with hepatocellular carcinoma.

Authors:  Y Shirai; S Kawata; N Ito; S Tamura; K Takaishi; S Kiso; H Tsushima; Y Matsuzawa
Journal:  Jpn J Cancer Res       Date:  1992-07
  6 in total

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