| Literature DB >> 17035019 |
Venkat R Gadhachanda1, Baogen Wu, Zhiwei Wang, Kelli L Kuhen, Jeremy Caldwell, Helmut Zondler, Harald Walter, Mark Havenhand, Yun He.
Abstract
A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.Entities:
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Year: 2006 PMID： 17035019 DOI： 10.1016/j.bmcl.2006.09.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823