| Literature DB >> 17034109 |
Pavel Broz1, Sergey Driamov, Joerg Ziegler, Nadav Ben-Haim, Stephan Marsch, Wolfgang Meier, Patrick Hunziker.
Abstract
To develop an intelligent sensor-effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4-6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted diagnostic and therapeutic applications in medicine.Entities:
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Year: 2006 PMID： 17034109 DOI： 10.1021/nl0619305
Source DB: PubMed Journal: Nano Lett ISSN： 1530-6984 Impact factor: 11.189