| Literature DB >> 17034088 |
Janina Kneipp1, Harald Kneipp, Margaret McLaughlin, Dennis Brown, Katrin Kneipp.
Abstract
Surface-enhanced Raman (SERS) signatures were measured from single living cells at different times after the uptake of gold nanoparticles. The spectra are indicative of chemical changes in the environment of the nanostructures over time. The increase of the SERS signal strength and parallel TEM studies indicate the formation of nanoaggregates providing optimum SERS enhancement for ultrasensitive probing inside the endosomal compartment. The results have implications for medical and biotechnology applications of SERS nanosensors in cells.Entities:
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Year: 2006 PMID: 17034088 DOI: 10.1021/nl061517x
Source DB: PubMed Journal: Nano Lett ISSN: 1530-6984 Impact factor: 11.189