New advances in the molecular and cellular biology of the small intestine.

Research into the structure and function of the small intestinal mucosa is becoming increasingly focused on the molecular and cellular biology of this fascinating tissue. There is a growing understanding of the factors determining the expression of specific genes at different stages of development and differentiation in the multiple cell types, and several important transcription factors have emerged. Recent publications have included studies of the effects of commensal bacteria on gene expression and the molecules producing apoptosis. Mechanisms of the intestinal adaptation to injury or surgery involve a number of hormones; current research has shown a major role for glucagon-like peptide 2.