CONTEXT: Prior studies of Mexican Americans described association of lipoprotein lipase (LPL) gene haplotypes with insulin sensitivity/resistance and atherosclerosis. The most common haplotype (haplotype 1) was protective, whereas the fourth most common haplotype (haplotype 4) conferred risk for insulin resistance and atherosclerosis. OBJECTIVE: In this study of Hispanics in the Insulin Resistance Atherosclerosis Study Family Study, we sought to replicate LPL haplotype association with insulin sensitivity/resistance. DESIGN: LPL haplotypes based on 12 single nucleotide polymorphisms were analyzed for association with indexes of insulin sensitivity and other metabolic and adiposity measures. SETTING: This study was conducted in the general community of San Antonio, Texas, and San Luis Valley, Colorado. PARTICIPANTS: Participants in this study were 978 members of 86 Hispanic families. MAIN OUTCOME MEASURES: LPL haplogenotype, metabolic phenotypes, and adiposity were measured in this study. RESULTS: The haplotype structure was identical with that observed in prior studies. Among 978 phenotyped subjects, haplotype 1 was associated with decreased fasting insulin (P = 0.01), and haplotype 4 was associated with increased fasting insulin (P = 0.02) and increased visceral fat mass (P = 0.002). Insulin sensitivity, derived from iv glucose tolerance testing, tended (P > 0.1) to be higher with haplotype 1 (S(I) = 1.72) and lower with haplotype 4 (S(I)=1.38). Haplotype 2 was associated with increases in fasting insulin, triglycerides (TGs), TG to high-density lipoprotein-cholesterol ratio, and apolipoprotein B (P = 0.01-0.04). CONCLUSIONS: This study independently replicates our prior results of LPL haplotypes 1 and 4 as associated with measures of insulin sensitivity and resistance, respectively. Haplotype 4 may confer insulin resistance by increasing visceral fat. Haplotype 2 was identified as a new risk haplotype, suggesting the complex nature of LPL's effect on features of the insulin resistance syndrome.
CONTEXT: Prior studies of Mexican Americans described association of lipoprotein lipase (LPL) gene haplotypes with insulin sensitivity/resistance and atherosclerosis. The most common haplotype (haplotype 1) was protective, whereas the fourth most common haplotype (haplotype 4) conferred risk for insulin resistance and atherosclerosis. OBJECTIVE: In this study of Hispanics in the Insulin Resistance Atherosclerosis Study Family Study, we sought to replicate LPL haplotype association with insulin sensitivity/resistance. DESIGN:LPL haplotypes based on 12 single nucleotide polymorphisms were analyzed for association with indexes of insulin sensitivity and other metabolic and adiposity measures. SETTING: This study was conducted in the general community of San Antonio, Texas, and San Luis Valley, Colorado. PARTICIPANTS: Participants in this study were 978 members of 86 Hispanic families. MAIN OUTCOME MEASURES: LPL haplogenotype, metabolic phenotypes, and adiposity were measured in this study. RESULTS: The haplotype structure was identical with that observed in prior studies. Among 978 phenotyped subjects, haplotype 1 was associated with decreased fasting insulin (P = 0.01), and haplotype 4 was associated with increased fasting insulin (P = 0.02) and increased visceral fat mass (P = 0.002). Insulin sensitivity, derived from iv glucose tolerance testing, tended (P > 0.1) to be higher with haplotype 1 (S(I) = 1.72) and lower with haplotype 4 (S(I)=1.38). Haplotype 2 was associated with increases in fasting insulin, triglycerides (TGs), TG to high-density lipoprotein-cholesterol ratio, and apolipoprotein B (P = 0.01-0.04). CONCLUSIONS: This study independently replicates our prior results of LPL haplotypes 1 and 4 as associated with measures of insulin sensitivity and resistance, respectively. Haplotype 4 may confer insulin resistance by increasing visceral fat. Haplotype 2 was identified as a new risk haplotype, suggesting the complex nature of LPL's effect on features of the insulin resistance syndrome.
Authors: Marc-Andre Cornier; Dana Dabelea; Teri L Hernandez; Rachel C Lindstrom; Amy J Steig; Nicole R Stob; Rachael E Van Pelt; Hong Wang; Robert H Eckel Journal: Endocr Rev Date: 2008-10-29 Impact factor: 19.871
Authors: Chunyu Liu; Aldi T Kraja; Jennifer A Smith; Jennifer A Brody; Nora Franceschini; Joshua C Bis; Kenneth Rice; Alanna C Morrison; Yingchang Lu; Stefan Weiss; Xiuqing Guo; Walter Palmas; Lisa W Martin; Yii-Der Ida Chen; Praveen Surendran; Fotios Drenos; James P Cook; Paul L Auer; Audrey Y Chu; Ayush Giri; Wei Zhao; Johanna Jakobsdottir; Li-An Lin; Jeanette M Stafford; Najaf Amin; Hao Mei; Jie Yao; Arend Voorman; Martin G Larson; Megan L Grove; Albert V Smith; Shih-Jen Hwang; Han Chen; Tianxiao Huan; Gulum Kosova; Nathan O Stitziel; Sekar Kathiresan; Nilesh Samani; Heribert Schunkert; Panos Deloukas; Man Li; Christian Fuchsberger; Cristian Pattaro; Mathias Gorski; Charles Kooperberg; George J Papanicolaou; Jacques E Rossouw; Jessica D Faul; Sharon L R Kardia; Claude Bouchard; Leslie J Raffel; André G Uitterlinden; Oscar H Franco; Ramachandran S Vasan; Christopher J O'Donnell; Kent D Taylor; Kiang Liu; Erwin P Bottinger; Omri Gottesman; E Warwick Daw; Franco Giulianini; Santhi Ganesh; Elias Salfati; Tamara B Harris; Lenore J Launer; Marcus Dörr; Stephan B Felix; Rainer Rettig; Henry Völzke; Eric Kim; Wen-Jane Lee; I-Te Lee; Wayne H-H Sheu; Krystal S Tsosie; Digna R Velez Edwards; Yongmei Liu; Adolfo Correa; David R Weir; Uwe Völker; Paul M Ridker; Eric Boerwinkle; Vilmundur Gudnason; Alexander P Reiner; Cornelia M van Duijn; Ingrid B Borecki; Todd L Edwards; Aravinda Chakravarti; Jerome I Rotter; Bruce M Psaty; Ruth J F Loos; Myriam Fornage; Georg B Ehret; Christopher Newton-Cheh; Daniel Levy; Daniel I Chasman Journal: Nat Genet Date: 2016-09-12 Impact factor: 41.307
Authors: K A Ayyappa; I Shatwan; D Bodhini; L R Bramwell; K Ramya; V Sudha; R M Anjana; J A Lovegrove; V Mohan; V Radha; K S Vimaleswaran Journal: Nutr Metab (Lond) Date: 2017-01-19 Impact factor: 4.169