| Literature DB >> 27618448 |
Chunyu Liu1,2,3, Aldi T Kraja4, Jennifer A Smith5, Jennifer A Brody6, Nora Franceschini7, Joshua C Bis6, Kenneth Rice8, Alanna C Morrison9, Yingchang Lu10, Stefan Weiss11,12, Xiuqing Guo13, Walter Palmas14, Lisa W Martin15, Yii-Der Ida Chen13, Praveen Surendran16, Fotios Drenos17,18, James P Cook19,20, Paul L Auer21, Audrey Y Chu1,3,22, Ayush Giri23, Wei Zhao5, Johanna Jakobsdottir24, Li-An Lin25, Jeanette M Stafford26, Najaf Amin27, Hao Mei28, Jie Yao13, Arend Voorman29, Martin G Larson1,2,30, Megan L Grove9, Albert V Smith24,31, Shih-Jen Hwang1,3, Han Chen32, Tianxiao Huan1,3, Gulum Kosova33,34, Nathan O Stitziel35, Sekar Kathiresan33,34, Nilesh Samani36,37, Heribert Schunkert38,39, Panos Deloukas40,41, Man Li42, Christian Fuchsberger43, Cristian Pattaro43, Mathias Gorski44, Charles Kooperberg45, George J Papanicolaou46, Jacques E Rossouw46, Jessica D Faul47, Sharon L R Kardia5, Claude Bouchard48, Leslie J Raffel49, André G Uitterlinden50,51, Oscar H Franco50, Ramachandran S Vasan1,52, Christopher J O'Donnell1,53,54,55, Kent D Taylor13, Kiang Liu56, Erwin P Bottinger10, Omri Gottesman10, E Warwick Daw4, Franco Giulianini22, Santhi Ganesh57,58, Elias Salfati59, Tamara B Harris60, Lenore J Launer61, Marcus Dörr11,62, Stephan B Felix11,62, Rainer Rettig11,63, Henry Völzke11,64,65, Eric Kim13, Wen-Jane Lee66, I-Te Lee67,68,69, Wayne H-H Sheu67,68,70,71, Krystal S Tsosie23, Digna R Velez Edwards23,72, Yongmei Liu73, Adolfo Correa74, David R Weir47, Uwe Völker11,12, Paul M Ridker22,75, Eric Boerwinkle9, Vilmundur Gudnason24,31, Alexander P Reiner76, Cornelia M van Duijn27, Ingrid B Borecki4, Todd L Edwards23,77, Aravinda Chakravarti59, Jerome I Rotter13,78, Bruce M Psaty6,76,79,80, Ruth J F Loos10,80, Myriam Fornage25, Georg B Ehret59,81, Christopher Newton-Cheh33,34,82, Daniel Levy1,3, Daniel I Chasman22,75.
Abstract
Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726 additional individuals (total n = 327,288). These blood pressure-associated loci are enriched for known variants for cardiometabolic traits. Associations were also observed for the aggregation of rare and low-frequency missense variants in three genes, NPR1, DBH, and PTPMT1. In addition, blood pressure associations at 39 previously reported loci were confirmed. The identified variants implicate biological pathways related to cardiometabolic traits, vascular function, and development. Several new variants are inferred to have roles in transcription or as hubs in protein-protein interaction networks. Genetic risk scores constructed from the identified variants were strongly associated with coronary disease and myocardial infarction. This large collection of blood pressure-associated loci suggests new therapeutic strategies for hypertension, emphasizing a link with cardiometabolic risk.Entities:
Mesh：
Year: 2016 PMID： 27618448 PMCID： PMC5320952 DOI： 10.1038/ng.3660
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307