Literature DB >> 1703147

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells.

U H Kim1, D Fink, H S Kim, D J Park, M L Contreras, G Guroff, S G Rhee.   

Abstract

PC12 cells contain at least three immunologically distinct phospholipase C (PLC) isozymes, PLC-beta, PLC-gamma, and PLC-delta. Treatment of PC12 cells with nerve growth factor (NGF) leads to an increase in the phosphorylation of PLC-gamma, but not of PLC-beta or PLC-delta. This increase can be seen in as little as 1 minute. The increased phosphorylation occurs on both serine and tyrosine residues, with the major increase being in the former. This result suggests the possibility that the NGF-dependent increase in phosphoinositide hydrolysis in PC12 cells is due to selective phosphorylation of PLC-gamma by serine and tyrosine protein kinases associated with the NGF receptor.

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Year:  1991        PMID： 1703147

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  34 in total

Review 1.  Epidermal growth factor receptor: elements of intracellular communication.

Authors:  S M Hernández-Sotomayor; G Carpenter
Journal:  J Membr Biol       Date:  1992-06       Impact factor: 1.843

2.  95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site.

Authors:  R M Stephens; G Sithanandam; T D Copeland; D R Kaplan; U R Rapp; D K Morrison
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272

Review 3.  Identification of tyrosine kinase Trk as a nerve growth factor receptor.

Authors:  A H Ross
Journal:  Cell Regul       Date:  1991-09

4.  Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

Authors:  M L Vetter; D Martin-Zanca; L F Parada; J M Bishop; D R Kaplan
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

5.  Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex.

Authors:  S O Meakin; E M Shooter
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

6.  The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.

Authors:  M M Berg; D W Sternberg; B L Hempstead; M V Chao
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

7.  Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6.

Authors:  S Ihara; K Nakajima; T Fukada; M Hibi; S Nagata; T Hirano; Y Fukui
Journal:  EMBO J       Date:  1997-09-01       Impact factor: 11.598

8.  SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells.

Authors:  S J Rabin; V Cleghon; D R Kaplan
Journal:  Mol Cell Biol       Date:  1993-04       Impact factor: 4.272

9.  A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions.

Authors:  G D'Arcangelo; S Halegoua
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

10.  Evidence for involvement of phospholipase C-gamma 2 in signal transduction of platelet-derived growth factor in vascular smooth-muscle cells.

Authors:  Y Homma; H Sakamoto; M Tsunoda; M Aoki; T Takenawa; T Ooyama
Journal:  Biochem J       Date:  1993-03-15       Impact factor: 3.857
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