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Literature DB >> 17030375

Possible antipsychotic effects of minocycline in patients with schizophrenia.

Tsuyoshi Miyaoka¹, Rei Yasukawa, Hideaki Yasuda, Maiko Hayashida, Takuji Inagaki, Jun Horiguchi.

Abstract

We present two cases of patients with schizophrenia treated with minocycline. Minocycline (a second-generation tetracycline) is an established and safe broad-spectrum antibiotic that crosses the blood-brain barrier, with additional efficacy for diseases such as acne and rheumatoid arthritis. Animal studies have suggested that minocycline may prevent progression of some neurological disorders. Moreover, it has been reported that minocycline might have antidepressant effects. We report two cases of acute schizophrenia with predominant catatonic symptoms that responded to minocycline.

Entities: Chemical Disease Species

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Year: 2006 PMID： 17030375 DOI： 10.1016/j.pnpbp.2006.08.013

Source DB: PubMed Journal: Prog Neuropsychopharmacol Biol Psychiatry ISSN： 0278-5846 Impact factor: 5.067

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Cited

27 in total

Review 1. Potential microbial origins of schizophrenia and their treatments.

Authors: S Hossein Fatemi
Journal: Drugs Today (Barc) Date: 2009-04 Impact factor: 2.245

Review 2. Microglia Activation and Schizophrenia: Lessons From the Effects of Minocycline on Postnatal Neurogenesis, Neuronal Survival and Synaptic Pruning.

Authors: Dragos Inta; Undine E Lang; Stefan Borgwardt; Andreas Meyer-Lindenberg; Peter Gass
Journal: Schizophr Bull Date: 2017-05-01 Impact factor: 9.306

Review 3. Glial modulators as potential treatments of psychostimulant abuse.

Authors: Patrick M Beardsley; Kurt F Hauser
Journal: Adv Pharmacol Date: 2014

Review 4. Viral infection, inflammation and schizophrenia.

Authors: Rachel E Kneeland; S Hossein Fatemi
Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2012-02-10 Impact factor: 5.067

5. Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions.

Authors: Janelle Drouin-Ouellet; Anna-Liisa Brownell; Martine Saint-Pierre; Caroline Fasano; Vincent Emond; Louis-Eric Trudeau; Daniel Lévesque; Francesca Cicchetti
Journal: Glia Date: 2011-02 Impact factor: 7.452

6. Adjunctive Minocycline in Clozapine-Treated Patients with Schizophrenia: Analyzing the Effects of Minocycline on Clozapine Plasma Levels.

Authors: Heidi J Wehring; Teresa Elsobky; Joseph P McEvoy; Gopal Vyas; Charles M Richardson; Robert P McMahon; Bethany A DiPaula; Fang Liu; Kelli Sullivan; Robert W Buchanan; Stephanie Feldman; Elizabeth M McMahon; Deanna L Kelly
Journal: Psychiatr Q Date: 2018-03

Possible antipsychotic effects of minocycline in patients with schizophrenia.

Review 1. Potential microbial origins of schizophrenia and their treatments.

Review 2. Microglia Activation and Schizophrenia: Lessons From the Effects of Minocycline on Postnatal Neurogenesis, Neuronal Survival and Synaptic Pruning.

Review 3. Glial modulators as potential treatments of psychostimulant abuse.

Review 4. Viral infection, inflammation and schizophrenia.

5. Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions.

6. Adjunctive Minocycline in Clozapine-Treated Patients with Schizophrenia: Analyzing the Effects of Minocycline on Clozapine Plasma Levels.

Review 7. Minocycline: therapeutic potential in psychiatry.

8. Antipsychotic-like effect of minocycline in a rat model.

9. Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice.

Review 10. Effects of Antipsychotic Drugs: Cross Talk Between the Nervous and Innate Immune System.