BACKGROUND: Exposure to the fungus Alternaria alternata is a risk factor for asthma. Few studies have examined Alternaria exposures in indoor environments. OBJECTIVE: We examined whether exposure to A alternata in US homes was associated with asthma-related outcomes. METHODS: The data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed a nationally representative sample of 831 housing units inhabited by 2456 individuals in 75 different locations throughout the United States. An interviewer-administered questionnaire obtained information on demographics, household characteristics, and occupants' health status. Exposure to A alternata was assessed by measuring concentrations of A alternata antigens in vacuumed dust samples using a polyclonal anti-A alternata antibody assay. Dust samples were collected from a bed, a sofa, or a chair, and from bedroom, living room, and kitchen floors. RESULTS: Lifetime prevalence of doctor-diagnosed asthma was 11.2%, and 6.9% of the study subjects reported active asthma symptoms in the past 12 months. The prevalence of current symptomatic asthma increased with increasing Alternaria concentrations in US homes; higher levels of A alternata antigens increased the odds of having asthma symptoms in the past year (relative to the lowest tertile, adjusted odds ratio was 1.52, 95% CI, 0.90-2.55 for the 2nd tertile; and 1.84, 95% CI, 1.18-2.85 for the 3rd tertile). CONCLUSION: Exposure to A alternata in US homes is associated with active asthma symptoms. CLINICAL IMPLICATIONS: Measures that reduce indoor exposure to A alternata may help control asthma exacerbations.
BACKGROUND: Exposure to the fungus Alternaria alternata is a risk factor for asthma. Few studies have examined Alternaria exposures in indoor environments. OBJECTIVE: We examined whether exposure to A alternata in US homes was associated with asthma-related outcomes. METHODS: The data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed a nationally representative sample of 831 housing units inhabited by 2456 individuals in 75 different locations throughout the United States. An interviewer-administered questionnaire obtained information on demographics, household characteristics, and occupants' health status. Exposure to A alternata was assessed by measuring concentrations of A alternata antigens in vacuumed dust samples using a polyclonal anti-A alternata antibody assay. Dust samples were collected from a bed, a sofa, or a chair, and from bedroom, living room, and kitchen floors. RESULTS: Lifetime prevalence of doctor-diagnosed asthma was 11.2%, and 6.9% of the study subjects reported active asthma symptoms in the past 12 months. The prevalence of current symptomatic asthma increased with increasing Alternaria concentrations in US homes; higher levels of A alternata antigens increased the odds of having asthma symptoms in the past year (relative to the lowest tertile, adjusted odds ratio was 1.52, 95% CI, 0.90-2.55 for the 2nd tertile; and 1.84, 95% CI, 1.18-2.85 for the 3rd tertile). CONCLUSION: Exposure to A alternata in US homes is associated with active asthma symptoms. CLINICAL IMPLICATIONS: Measures that reduce indoor exposure to A alternata may help control asthma exacerbations.
Authors: M S Perzanowski; R Sporik; S P Squillace; L E Gelber; R Call; M Carter; T A Platts-Mills Journal: J Allergy Clin Immunol Date: 1998-05 Impact factor: 10.793
Authors: R J Delfino; R S Zeiger; J M Seltzer; D H Street; R M Matteucci; P R Anderson; P Koutrakis Journal: Environ Health Perspect Date: 1997-06 Impact factor: 9.031
Authors: M T O'Hollaren; J W Yunginger; K P Offord; M J Somers; E J O'Connell; D J Ballard; M I Sachs Journal: N Engl J Med Date: 1991-02-07 Impact factor: 91.245
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