Literature DB >> 17029797

Synthesis and anti-microbial activity of pyrazolylbisindoles--promising anti-fungal compounds.

Ganesabaskaran Sivaprasad1, Paramasivan T Perumal, Vaiyapuri R Prabavathy, Narayanasamy Mathivanan.   

Abstract

A series of pyrazolylbisindole derivatives have been synthesized by reacting substituted pyrazole aldehydes with substituted indoles using phosphotungstic acid, a Keggin type heteropoly acid as catalyst. The synthesized pyrazolylbisindoles were evaluated for anti-microbial activities. The effect of pyrazolylbisindoles on the mycelial growth of plant pathogenic fungi is revealed. Entries 3c and 3d emerged as the most interesting compounds in this series exhibiting excellent anti-fungal activity.

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Year:  2006        PMID: 17029797     DOI: 10.1016/j.bmcl.2006.09.019

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  9 in total

1.  Catalyst-free visible-light-induced condensation to synthesize bis(indolyl)methanes and biological activity evaluation of them as potent human carboxylesterase 2 inhibitors.

Authors:  Yi-Shu Zhao; Hong-Li Ruan; Xiu-Yang Wang; Chen Chen; Pei-Fang Song; Cheng-Wei Lü; Li-Wei Zou
Journal:  RSC Adv       Date:  2019-12-03       Impact factor: 4.036

2.  4-Bromo-5-[(5,5-dimethyl-4,5-dihydro-isoxazol-3-yl)sulfonyl-meth-yl]-3-methyl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazole.

Authors:  Hong-Ju Ma; Qian-Fei Zhao; Xiang-Dong Mei; Jun Ning
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-10

3.  Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo.

Authors:  Xuan Zhao; WenLiang Dong; YuanDi Gao; Dong-Shoo Shin; Qing Ye; Le Su; Fan Jiang; BaoXiang Zhao; JunYing Miao
Journal:  Sci Rep       Date:  2017-06-20       Impact factor: 4.379

4.  The Hexameric Resorcinarene Capsule as a Brønsted Acid Catalyst for the Synthesis of Bis(heteroaryl)methanes in a Nanoconfined Space.

Authors:  Stefania Gambaro; Pellegrino La Manna; Margherita De Rosa; Annunziata Soriente; Carmen Talotta; Carmine Gaeta; Placido Neri
Journal:  Front Chem       Date:  2019-10-22       Impact factor: 5.221

5.  One-Pot Three-Component Coupling Reaction of α-Amino Aryl Ketones, Indoles, and Perbromomethane Under Mild Conditions.

Authors:  Hao Lu; Yuxuan Liu; Wei Deng; Renhua Qiu; Jiannan Xiang
Journal:  Front Chem       Date:  2022-02-04       Impact factor: 5.221

6.  SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance.

Authors:  Ornella Randazzo; Stella M Cascioferro; Camilla Pecoraro; Widad Ait Iddouch; Amir Avan; Barbara Parrino; Daniela Carbone; Ugo Perricone; Godefridus J Peters; Patrizia Diana; Elisa Giovannetti
Journal:  Cancer Drug Resist       Date:  2021-10-08

7.  Visible Light-Promoted Green and Sustainable Approach for One-Pot Synthesis of 4,4'-(Arylmethylene)bis(1H-pyrazol-5-ols), In Vitro Anticancer Activity, and Molecular Docking with Covid-19 Mpro.

Authors:  Anamika Gupta; Safia Iqbal; Mohd Kamil Hussain; Mohd Rehan Zaheer; Krapa Shankar
Journal:  ACS Omega       Date:  2022-09-14

8.  Iodine-catalyzed electrophilic substitution of indoles: Synthesis of (un)symmetrical diindolylmethanes with a quaternary carbon center.

Authors:  Thanigaimalai Pillaiyar; Masoud Sedaghati; Andhika B Mahardhika; Lukas L Wendt; Christa E Müller
Journal:  Beilstein J Org Chem       Date:  2021-06-18       Impact factor: 2.883

9.  Synthesis of bisindolylmethanes and their cytotoxicity properties.

Authors:  Kalla Reddi Mohan Naidu; Shaik Ibrahim Khalivulla; Syed Rasheed; Sharida Fakurazi; Palanisamy Arulselvan; Ola Lasekan; Faridah Abas
Journal:  Int J Mol Sci       Date:  2013-01-16       Impact factor: 5.923

  9 in total

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