Literature DB >> 17028218

Analysis of antibody response in humans to the type A OspC loop 5 domain and assessment of the potential utility of the loop 5 epitope in Lyme disease vaccine development.

Eric L Buckles1, Christopher G Earnhart, Richard T Marconi.   

Abstract

The OspC protein of Borrelia burgdorferi is an immunodominant antigen. Here we demonstrate that the loop 5 domain of type A OspC is surface exposed, elicits bactericidal antibody in mice, and is antigenic in humans. The data suggest that loop 5 may be suitable for inclusion in a polyvalent, chimeric OspC vaccinogen.

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Year:  2006        PMID： 17028218      PMCID： PMC1595320          DOI： 10.1128/CVI.00099-06

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  32 in total

1.  Toward the development of a synthetic group a streptococcal vaccine of high purity and broad protective coverage.

Authors:  Anikó Horváth; Colleen Olive; Levente Karpati; Hsien K Sun; Michael Good; Istvan Toth
Journal:  J Med Chem       Date:  2004-07-29       Impact factor: 7.446

2.  Environmental regulation and differential production of members of the Bdr protein family of Borrelia burgdorferi.

Authors:  David M Roberts; Melissa Caimano; John McDowell; Michael Theisen; Arne Holm; Edward Orff; David Nelson; Stephen Wikel; Justin Radolf; Richard T Marconi
Journal:  Infect Immun       Date:  2002-12       Impact factor: 3.441

3.  Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22 kDa protein (pC) in Escherichia coli.

Authors:  R Fuchs; S Jauris; F Lottspeich; V Preac-Mursic; B Wilske; E Soutschek
Journal:  Mol Microbiol       Date:  1992-02       Impact factor: 3.501

4.  Induction of an outer surface protein on Borrelia burgdorferi during tick feeding.

Authors:  T G Schwan; J Piesman; W T Golde; M C Dolan; P A Rosa
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

5.  Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen.

Authors:  W S Probert; R B LeFebvre
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

6.  C-terminal region of outer surface protein C binds borreliacidal antibodies in sera from patients with Lyme disease.

Authors:  Dean A Jobe; Steven D Lovrich; Ronald F Schell; Steven M Callister
Journal:  Clin Diagn Lab Immunol       Date:  2003-07

7.  Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi.

Authors:  B Wilske; V Preac-Mursic; S Jauris; A Hofmann; I Pradel; E Soutschek; E Schwab; G Will; G Wanner
Journal:  Infect Immun       Date:  1993-05       Impact factor: 3.441

8.  Polymorphism in ospC gene of Borrelia burgdorferi and immunoreactivity of OspC protein: implications for taxonomy and for use of OspC protein as a diagnostic antigen.

Authors:  M Theisen; B Frederiksen; A M Lebech; J Vuust; K Hansen
Journal:  J Clin Microbiol       Date:  1993-10       Impact factor: 5.948

9.  Genetic diversity among Borrelia strains determined by single-strand conformation polymorphism analysis of the ospC gene and its association with invasiveness.

Authors:  Vanessa Lagal; Danièle Postic; Eva Ruzic-Sabljic; Guy Baranton
Journal:  J Clin Microbiol       Date:  2003-11       Impact factor: 5.948

10.  Safety and immunogenicity of a recombinant multivalent group a streptococcal vaccine in healthy adults: phase 1 trial.

Authors:  Karen L Kotloff; Mary Corretti; Kathleen Palmer; James D Campbell; Mark A Reddish; Mary C Hu; Steven S Wasserman; James B Dale
Journal:  JAMA       Date:  2004-08-11       Impact factor: 56.272
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  20 in total

Review 1.  Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and Vaccination.

Authors:  Jerilyn R Izac; Richard T Marconi
Journal:  Vet Clin North Am Small Anim Pract       Date:  2019-04-06       Impact factor: 2.093

2.  Construction and analysis of variants of a polyvalent Lyme disease vaccine: approaches for improving the immune response to chimeric vaccinogens.

Authors:  Christopher G Earnhart; Richard T Marconi
Journal:  Vaccine       Date:  2007-01-17       Impact factor: 3.641

3.  OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine.

Authors:  Christopher G Earnhart; Richard T Marconi
Journal:  Clin Vaccine Immunol       Date:  2007-03-14

4.  Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses.

Authors:  Jerilyn R Izac; Andrew C Camire; Christopher G Earnhart; Monica E Embers; Rebecca A Funk; Edward B Breitschwerdt; Richard T Marconi
Journal:  Vaccine       Date:  2019-03-25       Impact factor: 3.641

5.  Enhanced Protective Immunogenicity of Homodimeric Borrelia burgdorferi Outer Surface Protein C.

Authors:  Diane G Edmondson; Sabitha Prabhakaran; Steven J Norris; Amy J Ullmann; Joe Piesman; Marc Dolan; Christian Probst; Christiane Radzimski; Winfried Stöcker; Lars Komorowski
Journal:  Clin Vaccine Immunol       Date:  2017-01-05

6.  Delineating Surface Epitopes of Lyme Disease Pathogen Targeted by Highly Protective Antibodies of New Zealand White Rabbits.

Authors:  Artem S Rogovskyy; Salvador Eugenio C Caoili; Yurij Ionov; Helen Piontkivska; Pavel Skums; Viachaslau Tsyvina; Alex Zelikovsky; Suryakant D Waghela
Journal:  Infect Immun       Date:  2019-07-23       Impact factor: 3.441

7.  Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment.

Authors:  Christopher G Earnhart; Delacy V Leblanc; Katie E Alix; Daniel C Desrosiers; Justin D Radolf; Richard T Marconi
Journal:  Mol Microbiol       Date:  2010-02-28       Impact factor: 3.501

8.  Rapid decline of OspC borreliacidal antibodies following treatment of patients with early Lyme disease.

Authors:  Dean A Jobe; Todd J Kowalski; Marissa Bloemke; S D Lovrich; Steven M Callister
Journal:  Clin Vaccine Immunol       Date:  2011-04-20

9.  Identification of Borrelia burgdorferi ospC genotypes in canine tissue following tick infestation: implications for Lyme disease vaccine and diagnostic assay design.

Authors:  D V L Rhodes; C G Earnhart; T N Mather; P F M Meeus; R T Marconi
Journal:  Vet J       Date:  2013-08-17       Impact factor: 2.688

10.  Antibody profiling of a Borreliella burgdorferi (Lyme disease) C6 antibody positive, symptomatic Rottweiler and her pups.

Authors:  A L Hatke; D R Green; K Stasiak; R T Marconi
Journal:  Vet J       Date:  2020-07-05       Impact factor: 2.688
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