Literature DB >> 17360854

OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine.

Christopher G Earnhart1, Richard T Marconi.   

Abstract

Using available Borrelia outer surface protein C (OspC) sequences, a phylogenetic analysis was undertaken to delineate the number of antigenic domains required for inclusion in a broadly protective, chimeric, OspC-based Lyme disease vaccine. The data indicate that approximately 34 would be required and that an OspC-based vaccinogen is feasible.

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Year:  2007        PMID： 17360854      PMCID： PMC1865620          DOI： 10.1128/CVI.00409-06

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  47 in total

1.  Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi.

Authors:  C Eicken; V Sharma; T Klabunde; R T Owens; D S Pikas; M Höök; J C Sacchettini
Journal:  J Biol Chem       Date:  2001-01-03       Impact factor: 5.157

Review 2.  The implications of a low rate of horizontal transfer in Borrelia.

Authors:  D E Dykhuizen; G Baranton
Journal:  Trends Microbiol       Date:  2001-07       Impact factor: 17.079

3.  Geographic uniformity of the Lyme disease spirochete (Borrelia burgdorferi) and its shared history with tick vector (Ixodes scapularis) in the Northeastern United States.

Authors:  Wei-Gang Qiu; Daniel E Dykhuizen; Michael S Acosta; Benjamin J Luft
Journal:  Genetics       Date:  2002-03       Impact factor: 4.562

4.  Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.

Authors:  D Kumaran; S Eswaramoorthy; B J Luft; S Koide; J J Dunn; C L Lawson; S Swaminathan
Journal:  EMBO J       Date:  2001-03-01       Impact factor: 11.598

5.  Transduction by phiBB-1, a bacteriophage of Borrelia burgdorferi.

Authors:  C H Eggers; B J Kimmel; J L Bono; A F Elias; P Rosa; D S Samuels
Journal:  J Bacteriol       Date:  2001-08       Impact factor: 3.490

6.  Electrotransformation of the spirochete Borrelia burgdorferi.

Authors:  D S Samuels
Journal:  Methods Mol Biol       Date:  1995

7.  DNA vaccines expressing a fusion product of outer surface proteins A and C from Borrelia burgdorferi induce protective antibodies suitable for prophylaxis but Not for resolution of Lyme disease.

Authors:  R Wallich; A Siebers; O Jahraus; C Brenner; T Stehle; M M Simon
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

8.  Stability of Borrelia burgdorferi outer surface protein C under immune selection pressure.

Authors:  E Hodzic; S Feng; S W Barthold
Journal:  J Infect Dis       Date:  2000-02       Impact factor: 5.226

Review 9.  Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi.

Authors:  T G Schwan
Journal:  Biochem Soc Trans       Date:  2003-02       Impact factor: 5.407

10.  Genetic diversity of the outer surface protein C gene of southern Borrelia isolates and its possible epidemiological, clinical, and pathogenetic implications.

Authors:  Tao Lin; James H Oliver; Lihui Gao
Journal:  J Clin Microbiol       Date:  2002-07       Impact factor: 5.948
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  29 in total

Review 1.  Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and Vaccination.

Authors:  Jerilyn R Izac; Richard T Marconi
Journal:  Vet Clin North Am Small Anim Pract       Date:  2019-04-06       Impact factor: 2.093

2.  Epitope mapping of Borrelia burgdorferi OspC protein in homodimeric fold.

Authors:  Adam Norek; Lubomír Janda
Journal:  Protein Sci       Date:  2017-02-11       Impact factor: 6.725

Review 3.  Lyme arthritis: current concepts and a change in paradigm.

Authors:  Dean T Nardelli; Steven M Callister; Ronald F Schell
Journal:  Clin Vaccine Immunol       Date:  2007-11-14

4.  Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses.

Authors:  Jerilyn R Izac; Andrew C Camire; Christopher G Earnhart; Monica E Embers; Rebecca A Funk; Edward B Breitschwerdt; Richard T Marconi
Journal:  Vaccine       Date:  2019-03-25       Impact factor: 3.641

5.  Enhanced Protective Immunogenicity of Homodimeric Borrelia burgdorferi Outer Surface Protein C.

Authors:  Diane G Edmondson; Sabitha Prabhakaran; Steven J Norris; Amy J Ullmann; Joe Piesman; Marc Dolan; Christian Probst; Christiane Radzimski; Winfried Stöcker; Lars Komorowski
Journal:  Clin Vaccine Immunol       Date:  2017-01-05

6.  Evaluation of the Borrelia burgdorferi BBA64 protein as a protective immunogen in mice.

Authors:  Kevin S Brandt; Toni G Patton; Anna S Allard; Melissa J Caimano; Justin D Radolf; Robert D Gilmore
Journal:  Clin Vaccine Immunol       Date:  2014-02-05

7.  Comprehensive seroprofiling of sixteen B. burgdorferi OspC: implications for Lyme disease diagnostics design.

Authors:  Larisa Ivanova; Iva Christova; Vera Neves; Miguel Aroso; Luciana Meirelles; Dustin Brisson; Maria Gomes-Solecki
Journal:  Clin Immunol       Date:  2009-07-02       Impact factor: 3.969

8.  Identification of Borrelia burgdorferi ospC genotypes in canine tissue following tick infestation: implications for Lyme disease vaccine and diagnostic assay design.

Authors:  D V L Rhodes; C G Earnhart; T N Mather; P F M Meeus; R T Marconi
Journal:  Vet J       Date:  2013-08-17       Impact factor: 2.688

9.  Live Attenuated Borrelia burgdorferi Targeted Mutants in an Infectious Strain Background Protect Mice from Challenge Infection.

Authors:  Beth L Hahn; Lavinia J Padmore; Laura C Ristow; Michael W Curtis; Jenifer Coburn
Journal:  Clin Vaccine Immunol       Date:  2016-08-05

10.  Novel Diagnosis of Lyme Disease: Potential for CAM Intervention.

Authors:  Aristo Vojdani; Frank Hebroni; Yaniv Raphael; Jonathan Erde; Bernard Raxlen
Journal:  Evid Based Complement Alternat Med       Date:  2007-10-15       Impact factor: 2.629
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