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Literature DB >> 1702747

Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins.

Abstract

Cultured human amniotic epithelial cells (HAEC) were found by immunofluorescence microscopy to express three complement inhibitory membrane proteins, CD59 antigen, decay-accelerating factor (DAF) and membrane attack complex (MAC) inhibitory protein (MIP), on their surfaces. The effects of incubation with Fab2 fragments of monoclonal antibodies (mAb) raised against these proteins on susceptibility of sensitized cells to lysis by homologous complement was examined. Percentage cell lysis was markedly increased in the presence of Fab2 anti-CD59 and to a lesser, but significant, extent in the presence of Fab2 anti-DAF. Fab2 anti-MIP did not alter the sensitivity of the cells to lysis by complement.

Entities: Gene Species

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Year: 1990 PMID： 1702747 PMCID： PMC1384423

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

22 in total

1. Presence of a membrane attack complex inhibiting protein on the human epithelial cell line HeLa.

Authors: B P Morgan; M G Olavesen; M J Watts
Journal: Biochem Soc Trans Date: 1990-08 Impact factor: 5.407

Review 2. The homologous species restriction of the complement attack: structure and function of the C8 binding protein.

Authors: G M Hänsch
Journal: Curr Top Microbiol Immunol Date: 1989 Impact factor: 4.291

3. Isolation of a human erythrocyte membrane protein capable of inhibiting expression of homologous complement transmembrane channels.

Authors: L S Zalman; L M Wood; H J Müller-Eberhard
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

4. Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels.

Authors: Y Sugita; Y Nakano; M Tomita
Journal: J Biochem Date: 1988-10 Impact factor: 3.387

5. The formation of HL-A antibodies in pregnancy. The antigenicity of aborted and term fetuses.

Authors: J Burke; K Johansen
Journal: J Obstet Gynaecol Br Commonw Date: 1974-03

6. Surface membrane expression by human blood leukocytes and platelets of decay-accelerating factor, a regulatory protein of the complement system.

Authors: A Nicholson-Weller; J P March; C E Rosen; D B Spicer; K F Austen
Journal: Blood Date: 1985-05 Impact factor: 22.113

7. The complement membrane attack complex stimulates the prostanoid production of cultured glomerular epithelial cells.

Authors: G M Hänsch; M Betz; J Günther; K O Rother; B Sterzel
Journal: Int Arch Allergy Appl Immunol Date: 1988

8. CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.

Authors: A Davies; D L Simmons; G Hale; R A Harrison; H Tighe; P J Lachmann; H Waldmann
Journal: J Exp Med Date: 1989-09-01 Impact factor: 14.307

9. Decay-accelerating factor is present on cultured human umbilical vein endothelial cells.

Authors: A S Asch; T Kinoshita; E A Jaffe; V Nussenzweig
Journal: J Exp Med Date: 1986-01-01 Impact factor: 14.307

10. Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids.

Authors: M E Medof; E I Walter; J L Rutgers; D M Knowles; V Nussenzweig
Journal: J Exp Med Date: 1987-03-01 Impact factor: 14.307

8 in total

1. Isolation and characterization of the complement-inhibiting protein CD59 antigen from platelet membranes.

Authors: B P Morgan
Journal: Biochem J Date: 1992-03-01 Impact factor: 3.857

2. Characterization of the membrane attack complex inhibitory protein CD59 antigen on human amniotic cells and in amniotic fluid.

Authors: I A Rooney; B P Morgan
Journal: Immunology Date: 1992-08 Impact factor: 7.397

Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins.

1. Presence of a membrane attack complex inhibiting protein on the human epithelial cell line HeLa.

Review 2. The homologous species restriction of the complement attack: structure and function of the C8 binding protein.

3. Isolation of a human erythrocyte membrane protein capable of inhibiting expression of homologous complement transmembrane channels.

4. Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels.

5. The formation of HL-A antibodies in pregnancy. The antigenicity of aborted and term fetuses.

6. Surface membrane expression by human blood leukocytes and platelets of decay-accelerating factor, a regulatory protein of the complement system.

7. The complement membrane attack complex stimulates the prostanoid production of cultured glomerular epithelial cells.

8. CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.

9. Decay-accelerating factor is present on cultured human umbilical vein endothelial cells.

10. Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids.

1. Isolation and characterization of the complement-inhibiting protein CD59 antigen from platelet membranes.

2. Characterization of the membrane attack complex inhibitory protein CD59 antigen on human amniotic cells and in amniotic fluid.

Review 3. Complement in human reproduction: activation and control.

Review 4. Membrane proteins that protect against complement lysis.

5. Expression and function of membrane attack complex inhibitory proteins on thyroid follicular cells.

Review 6. Amnion-derived stem cells: in quest of clinical applications.

7. Both freshly prepared and frozen-stored amniotic membrane cells express the complement inhibitor CD59.

Review 8. Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications.