Literature DB >> 2416869

Decay-accelerating factor is present on cultured human umbilical vein endothelial cells.

A S Asch, T Kinoshita, E A Jaffe, V Nussenzweig.   

Abstract

Decay-accelerating factor (DAF) has been previously described only in cells of bone marrow origin where it serves as a negative modulator of complement activation. Using mAb against human DAF, we demonstrated the presence of DAF in human umbilical vein endothelial cells by immunofluorescence microscopy and flow cytometry. By means of an immunoradiometric assay we detected an average of 3.3 X 10(5) molecules of DAF on each cell. When immunoisolates were analyzed in Western blots, endothelial cell DAF comigrated with DAF purified from normal erythrocytes. DAF was synthesized by the endothelial cells since 35S-labeled DAF could be immunoisolated from HUVEC cultured in medium containing [35S]methionine. This is the first evidence for the presence of DAF in cells of extra-marrow origin. DAF may protect endothelial cells from complement-mediated injury.

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Year:  1986        PMID： 2416869      PMCID： PMC2188008          DOI： 10.1084/jem.163.1.221

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  19 in total

1.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

2.  Inhibition of complement by a substance isolated from human erythrocytes. II. Studies on the site and mechanism of action.

Authors:  E M Hoffmann
Journal:  Immunochemistry       Date:  1969-05

3.  Inhibition of complement by a substance isolated from human erythrocytes. I. Extraction from human erythrocyte stromata.

Authors:  E M Hoffman
Journal:  Immunochemistry       Date:  1969-05

4.  Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system.

Authors:  A Nicholson-Weller; J Burge; D T Fearon; P F Weller; K F Austen
Journal:  J Immunol       Date:  1982-07       Impact factor: 5.422

5.  "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.

Authors:  W N Burnette
Journal:  Anal Biochem       Date:  1981-04       Impact factor: 3.365

6.  Radioimmunolocalization of murine mammary tumor virus proteins in gels.

Authors:  J N Bausch; K S Prasad; S Spiegelman
Journal:  Anal Biochem       Date:  1982-01-15       Impact factor: 3.365

7.  Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.

Authors:  E A Jaffe; R L Nachman; C G Becker; C R Minick
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

8.  Synthesis and secretion of thrombospondin by cultured human endothelial cells.

Authors:  D F Mosher; M J Doyle; E A Jaffe
Journal:  J Cell Biol       Date:  1982-05       Impact factor: 10.539

9.  Serial propagation of human endothelial cells in vitro.

Authors:  T Maciag; G A Hoover; M B Stemerman; R Weinstein
Journal:  J Cell Biol       Date:  1981-11       Impact factor: 10.539

10.  Paroxysmal nocturnal hemoglobinuria: deficiency in factor H-like functions of the abnormal erythrocytes.

Authors:  M K Pangburn; R D Schreiber; J S Trombold; H J Müller-Eberhard
Journal:  J Exp Med       Date:  1983-06-01       Impact factor: 14.307
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  37 in total

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Authors:  T Tada; H Okada; N Okada; H Tateyama; H Suzuki; Y Takahashi; T Eimoto
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4.  Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment.

Authors:  D R Shafren; R C Bates; M V Agrez; R L Herd; G F Burns; R D Barry
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5.  Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

Authors:  C F Nathan
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6.  Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria in the Age of Eculizumab.

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7.  Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria.

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Review 8.  CR1 and the cell membrane proteins that bind C3 and C4. A basic and clinical review.

Authors:  J G Wilson; N A Andriopoulos; D T Fearon
Journal:  Immunol Res       Date:  1987       Impact factor: 2.829

9.  Role of complement activation in obliterative bronchiolitis post-lung transplantation.

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Journal:  J Immunol       Date:  2013-09-16       Impact factor: 5.422

10.  Expression of decay-accelerating factor on synovial lining cells in inflammatory and degenerative arthritides.

Authors:  A Tarkowski; C Trollmo; P S Seifert; G K Hansson
Journal:  Rheumatol Int       Date:  1992       Impact factor: 2.631
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