Literature DB >> 1702643

Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor.

R MacKinnon1, L Heginbotham, T Abramson.   

Abstract

The Shaker K+ channel belongs to a family of structurally related voltage-activated cation channels that play a central role in cellular electrical signaling. By studying multiple site-directed mutants of the Shaker K+ channel, a region that forms the binding site for a pore-blocking scorpion toxin has been identified. The region contains a sequence that is highly conserved among cloned K+ channels and may contribute to the formation of the ion conduction pore.

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Year:  1990        PMID： 1702643     DOI： 10.1016/0896-6273(90)90335-d

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  55 in total

1.  Role of individual surface charges of voltage-gated K channels.

Authors:  F Elinder; P Arhem
Journal:  Biophys J       Date:  1999-09       Impact factor: 4.033

2.  Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles.

Authors:  Mats A L Eriksson; Benoît Roux
Journal:  Biophys J       Date:  2002-11       Impact factor: 4.033

3.  A point mutation in a Shaker K+ channel changes its charybdotoxin binding site from low to high affinity.

Authors:  S A Goldstein; C Miller
Journal:  Biophys J       Date:  1992-04       Impact factor: 4.033

4.  State-independent block of BK channels by an intracellular quaternary ammonium.

Authors:  Christina M Wilkens; Richard W Aldrich
Journal:  J Gen Physiol       Date:  2006-09       Impact factor: 4.086

Review 5.  Molecular diversity and regulation of renal potassium channels.

Authors:  Steven C Hebert; Gary Desir; Gerhard Giebisch; Wenhui Wang
Journal:  Physiol Rev       Date:  2005-01       Impact factor: 37.312

6.  A single nonpolar residue in the deep pore of related K+ channels acts as a K+:Rb+ conductance switch.

Authors:  G E Kirsch; J A Drewe; M Taglialatela; R H Joho; M DeBiasi; H A Hartmann; A M Brown
Journal:  Biophys J       Date:  1992-04       Impact factor: 4.033

7.  Primary structure of a calcium channel that is highly expressed in the rat cerebellum.

Authors:  T V Starr; W Prystay; T P Snutch
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

8.  Design, synthesis, and functional expression of a gene for charybdotoxin, a peptide blocker of K+ channels.

Authors:  C S Park; S F Hausdorff; C Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

Review 9.  Receptor-targeting mechanisms of pain-causing toxins: How ow?

Authors:  Christopher J Bohlen; David Julius
Journal:  Toxicon       Date:  2012-04-14       Impact factor: 3.033

10.  Use of Saccharomyces cerevisiae for patch-clamp analysis of heterologous membrane proteins: characterization of Kat1, an inward-rectifying K+ channel from Arabidopsis thaliana, and comparison with endogeneous yeast channels and carriers.

Authors:  A Bertl; J A Anderson; C L Slayman; R F Gaber
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205
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