| Literature DB >> 17025323 |
Roger Hunter1, Mino Caira, Nashia Stellenboom.
Abstract
A new synthesis of unsymmetrical disulfides is described. The reaction of a thiol R1SH with 1-chlorobenzotriazole (BtCl) at -78 degrees C in DCM affords a high-yielding conversion to R1SBt without appreciable formation of the symmetrical disulfide R1SSR1. R1SBt is then reacted with R2SH to form the unsymmetrical disulfide in a one-pot sequence with green character that avoids the use of toxic and harsh oxidizing agents. The methodology has been developed for synthesis of various types of disulfides.Entities:
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Year: 2006 PMID： 17025323 DOI： 10.1021/jo060693n
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354