OBJECTIVE: To analyze the discriminative ability, construct validity and sensitivity to change of the EQ-5D in paranoid schizophrenia (ICD-10 F20.0). METHODS: Data of 408 patients was analyzed in a longitudinal study by comparing EQ-5D with SF-36, CGI-S, PANSS, and GAF. RESULTS: EQ-5D showed considerable discriminative ability in the patient sample when compared to a representative population sample. If a measure used for comparison and a EQ-5D dimension were theoretically corresponding, the measure's mean score differed significantly between EQ-5D answer levels, with largest effect sizes for SF-36 scales (0.34<|d|<1.76), but rather small values for CGI-S, PANSS and GAF (|d|<0.5). EQ-5D VAS (mean 61.3) and German EQ-5D index (mean 0.84) showed rather moderate correlations with most other scales (0.18<|r|<0.62). ROC-analysis indicated a very low sensitivity to change of EQ VAS and German EQ-5D index (0.50<AUC<0.58). CONCLUSIONS: Although focusing on physical problems, the EQ-5D seems to have reasonable discriminative ability and construct validity, but very low sensitivity to change.
OBJECTIVE: To analyze the discriminative ability, construct validity and sensitivity to change of the EQ-5D in paranoid schizophrenia (ICD-10 F20.0). METHODS: Data of 408 patients was analyzed in a longitudinal study by comparing EQ-5D with SF-36, CGI-S, PANSS, and GAF. RESULTS: EQ-5D showed considerable discriminative ability in the patient sample when compared to a representative population sample. If a measure used for comparison and a EQ-5D dimension were theoretically corresponding, the measure's mean score differed significantly between EQ-5D answer levels, with largest effect sizes for SF-36 scales (0.34<|d|<1.76), but rather small values for CGI-S, PANSS and GAF (|d|<0.5). EQ-5D VAS (mean 61.3) and German EQ-5D index (mean 0.84) showed rather moderate correlations with most other scales (0.18<|r|<0.62). ROC-analysis indicated a very low sensitivity to change of EQ VAS and German EQ-5D index (0.50<AUC<0.58). CONCLUSIONS: Although focusing on physical problems, the EQ-5D seems to have reasonable discriminative ability and construct validity, but very low sensitivity to change.
Authors: M Drukker; M Joore; J van Os; S Sytema; G Driessen; M Bak; Ph Delespaul Journal: Epidemiol Psychiatr Sci Date: 2012-05-22 Impact factor: 6.892
Authors: J Stochl; T Croudace; J Perez; M Birchwood; H Lester; M Marshall; T Amos; V Sharma; D Fowler; P B Jones Journal: Qual Life Res Date: 2012-06-17 Impact factor: 4.147