PURPOSE: To evaluate the psychometric properties of the EQ-5D and the usefulness of this instrument in psychiatric practice as a measure of health-related quality of life (HRQoL) in a sample of young adults with first-episode psychosis. METHODS: The validity of individual questionnaire items is studied using an Item Response/Latent Trait Theory modeling approach. Sensitivity of response patterns on EQ-5D items to particular diagnostic subtypes of psychosis is investigated using a finite mixture modeling approach through latent class analysis. Finally, a structural equation modeling framework is used to study differential item functioning via a multigroup approach. RESULTS: Results suggest that the data closely correspond to the Rasch Rating Scale Model, and therefore that EQ-5D latent scores are equal interval measures. Despite comprising relatively few items, the instrument yields reliable measures of HRQoL for group comparisons and cost-effectiveness evaluation, but EQ-5D score is too imprecise for the assessment of HRQoL for clinical purposes at the individual level. A significant relationship was found between EQ-5D responses and type of psychosis due to inclusion of item anxiety/depression in EQ-5D. Two items (anxiety/depression, functioning in usual activities) showed an ethnicity bias. CONCLUSIONS: Psychometric evidence confirmed the EQ-5D to be a valid, interval measure that is scalable according to Rasch principles.
PURPOSE: To evaluate the psychometric properties of the EQ-5D and the usefulness of this instrument in psychiatric practice as a measure of health-related quality of life (HRQoL) in a sample of young adults with first-episode psychosis. METHODS: The validity of individual questionnaire items is studied using an Item Response/Latent Trait Theory modeling approach. Sensitivity of response patterns on EQ-5D items to particular diagnostic subtypes of psychosis is investigated using a finite mixture modeling approach through latent class analysis. Finally, a structural equation modeling framework is used to study differential item functioning via a multigroup approach. RESULTS: Results suggest that the data closely correspond to the Rasch Rating Scale Model, and therefore that EQ-5D latent scores are equal interval measures. Despite comprising relatively few items, the instrument yields reliable measures of HRQoL for group comparisons and cost-effectiveness evaluation, but EQ-5D score is too imprecise for the assessment of HRQoL for clinical purposes at the individual level. A significant relationship was found between EQ-5D responses and type of psychosis due to inclusion of item anxiety/depression in EQ-5D. Two items (anxiety/depression, functioning in usual activities) showed an ethnicity bias. CONCLUSIONS: Psychometric evidence confirmed the EQ-5D to be a valid, interval measure that is scalable according to Rasch principles.
Authors: Kirstie L Haywood; Andrew M Garratt; Ranjit Lall; Jan Fereday Smith; Sarah E Lamb Journal: Qual Life Res Date: 2008-02-15 Impact factor: 4.147
Authors: Jochen O Mierau; Daphne Kann-Weedage; Pieter J Hoekstra; Lisan Spiegelaar; Danielle E M C Jansen; Karin M Vermeulen; Sijmen A Reijneveld; Barbara J van den Hoofdakker; Erik Buskens; M Elske van den Akker-van Marle; Carmen D Dirksen; Annabeth P Groenman Journal: BMC Pediatr Date: 2020-07-03 Impact factor: 2.125
Authors: Polly-Anna Ashford; Clare Knight; Margaret Heslin; Allan B Clark; Mona Kanaan; Ushma Patel; Freya Stuart; Thomas Kabir; Nick Grey; Hannah Murray; J Hodgekins; Nesta Reeve; Nicola Marshall; Michelle Painter; James Clarke; Debra Russo; Jan Stochl; Maria Leathersich; Martin Pond; David Fowler; Paul French; Ann Marie Swart; Mary Dixon-Woods; Sarah Byford; Peter B Jones; Jesus Perez Journal: BMJ Open Date: 2022-06-22 Impact factor: 3.006