Literature DB >> 17023662

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.

Zhe-Yu Chen1, Deqiang Jing, Kevin G Bath, Alessandro Ieraci, Tanvir Khan, Chia-Jen Siao, Daniel G Herrera, Miklos Toth, Chingwen Yang, Bruce S McEwen, Barbara L Hempstead, Francis S Lee.   

Abstract

A common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated with alterations in brain anatomy and memory, but its relevance to clinical disorders is unclear. We generated a variant BDNF mouse (BDNF(Met/Met)) that reproduces the phenotypic hallmarks in humans with the variant allele. BDNF(Met) was expressed in brain at normal levels, but its secretion from neurons was defective. When placed in stressful settings, BDNF(Met/Met) mice exhibited increased anxiety-related behaviors that were not normalized by the antidepressant, fluoxetine. A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders.

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Year:  2006        PMID： 17023662      PMCID： PMC1880880          DOI： 10.1126/science.1129663

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  28 in total

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  543 in total

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7.  BDNF Val66Met polymorphism tunes frontolimbic circuitry during affective contextual learning.

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Review 8.  Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.

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10.  An adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke.

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