Literature DB >> 15537879

The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.

Lukas Pezawas1, Beth A Verchinski, Venkata S Mattay, Joseph H Callicott, Bhaskar S Kolachana, Richard E Straub, Michael F Egan, Andreas Meyer-Lindenberg, Daniel R Weinberger.   

Abstract

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15537879      PMCID： PMC6730170          DOI： 10.1523/JNEUROSCI.2680-04.2004

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  347 in total

1.  The role of brain-derived neurotrophic factor genotype, parental depression, and relationship discord in predicting early-emerging negative emotionality.

Authors:  Elizabeth P Hayden; Daniel N Klein; Lea R Dougherty; Thomas M Olino; Margaret W Dyson; C Emily Durbin; Haroon I Sheikh; Shiva M Singh
Journal:  Psychol Sci       Date:  2010-10-04

2.  Heritability of volumetric brain changes and height in children entering puberty.

Authors:  Inge L C van Soelen; Rachel M Brouwer; G Caroline M van Baal; Hugo G Schnack; Jiska S Peper; Lei Chen; René S Kahn; Dorret I Boomsma; Hilleke E Hulshoff Pol
Journal:  Hum Brain Mapp       Date:  2011-12-03       Impact factor: 5.038

Review 3.  BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.

Authors:  J J Rakofsky; K J Ressler; B W Dunlop
Journal:  Mol Psychiatry       Date:  2011-09-20       Impact factor: 15.992

4.  Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex.

Authors:  Rong-Jian Liu; Francis S Lee; Xiao-Yuan Li; Francis Bambico; Ronald S Duman; George K Aghajanian
Journal:  Biol Psychiatry       Date:  2011-10-29       Impact factor: 13.382

5.  Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits.

Authors:  A Terracciano; B Martin; D Ansari; T Tanaka; L Ferrucci; S Maudsley; M P Mattson; P T Costa
Journal:  Genes Brain Behav       Date:  2010-03-22       Impact factor: 3.449

6.  Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence.

Authors:  Marcin Wojnar; Kirk J Brower; Stephen Strobbe; Mark Ilgen; Halina Matsumoto; Izabela Nowosad; Elzbieta Sliwerska; Margit Burmeister
Journal:  Alcohol Clin Exp Res       Date:  2009-01-27       Impact factor: 3.455

Review 7.  Genetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder.

Authors:  Andrew J Levine; Stella E Panos; Steve Horvath
Journal:  J Acquir Immune Defic Syndr       Date:  2014-04-01       Impact factor: 3.731

8.  Multimodal imaging of a tescalcin (TESC)-regulating polymorphism (rs7294919)-specific effects on hippocampal gray matter structure.

Authors:  U Dannlowski; H J Grabe; K Wittfeld; J Klaus; C Konrad; D Grotegerd; R Redlich; T Suslow; N Opel; P Ohrmann; J Bauer; P Zwanzger; I Laeger; C Hohoff; V Arolt; W Heindel; M Deppe; K Domschke; K Hegenscheid; H Völzke; D Stacey; H Meyer Zu Schwabedissen; H Kugel; B T Baune
Journal:  Mol Psychiatry       Date:  2014-04-29       Impact factor: 15.992

9.  Impact of interacting functional variants in COMT on regional gray matter volume in human brain.

Authors:  Robyn Honea; Beth A Verchinski; Lukas Pezawas; Bhaskar S Kolachana; Joseph H Callicott; Venkata S Mattay; Daniel R Weinberger; Andreas Meyer-Lindenberg
Journal:  Neuroimage       Date:  2008-11-21       Impact factor: 6.556

10.  What keeps a body moving? The brain-derived neurotrophic factor val66met polymorphism and intrinsic motivation to exercise in humans.

Authors:  Ann E Caldwell Hooper; Angela D Bryan; Martin S Hagger
Journal:  J Behav Med       Date:  2014-05-08
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.