Literature DB >> 170223

Transformation of mouse cells after infection with ultraviolet irradiation-inactivated herpes simplex virus type 2.

A L Boyd, T W Orme.   

Abstract

A transformed mouse cell line (H238) was obtained following the infection of 238 mouse cells with ultraviolet (UV) irradiation-inactivated herpes simplex virus type 2 (HSV-2). The transformed cells produced tumors with a 100% incidence within 8 weeks in 6-week-old syngeneic BALB/c mice at an inoculum of 1 times 10(6). Indirect immunofluorescence (IF) tests revealed the presence of HSV antigens in the transformed cells. Antibodies to HSV-2 were found in the sera of tumor-bearing animals by neutralization and IF techniques. Neither HSV-2 infectious virus nor viral antigens could be detected by the transfer of transformed-cell DNA into permissive cells.

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Year:  1975        PMID： 170223     DOI： 10.1002/ijc.2910160403

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  10 in total

1.  Effect of actinomycin D on the expression of herpes simplex virus-common surface antigen in cells transformed by herpes simplex virus type 2.

Authors:  S Kimura; K Okazaki; N Yoshida; Y Ohnishi
Journal:  J Virol       Date:  1979-01       Impact factor: 5.103

2.  Mechanisms of expression of herpes simplex virus-common surface antigens in clonal cells of a herpes simplex virus type 2-transformed line.

Authors:  K Okazaki; Y Ohnishi; N Yoshida; S Kimura
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103

3.  Cross-reacting herpes simplex virus antigens in hamster and mouse cells transformed by ultraviolet light-inactivated herpes simplex virus type 2.

Authors:  A L Boyd
Journal:  Infect Immun       Date:  1976-03       Impact factor: 3.441

4.  Detection of herpes simplex virus type 2 glycoproteins expressed in virus-transformed rat cells.

Authors:  J G Lewis; L S Kucera; R Eberle; R J Courtney
Journal:  J Virol       Date:  1982-04       Impact factor: 5.103

5.  Biochemical transformation by temperature-sensitive mutants of herpes simplex virus type 1.

Authors:  F Rapp; N Turner; P A Schaffer
Journal:  J Virol       Date:  1980-06       Impact factor: 5.103

6.  Effects of the removal of adherent and phagocytic cells on the spleen cell lymphoproliferative response of tumor-bearing mice.

Authors:  A M Hyde; R B Stagg; R McEachron; R L Nutter
Journal:  Cancer Immunol Immunother       Date:  1985       Impact factor: 6.968

7.  Expression of an early, nonstructural antigen of herpes simplex virus in cell transformed in vitro by herpes simplex virus.

Authors:  V L Flannery; R J Courtney; P A Schaffer
Journal:  J Virol       Date:  1977-01       Impact factor: 5.103

8.  Blocked herpes simplex virus type 2-specific DNA synthesis in simian virus 40-transformed hamster cells permissive for herpes simplex virus type 1.

Authors:  D A Cheresh; H Haines
Journal:  Infect Immun       Date:  1983-08       Impact factor: 3.441

9.  Transformation of rodent cells by a cloned DNA fragment of herpes simplex virus type 2.

Authors:  D A Galloway; J K McDougall
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103

10.  The interaction of Herpes Simplex Virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus.

Authors:  D Mochizuki; S Hedrick; J Watson; D T Kingsbury
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307
  10 in total

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