| Literature DB >> 17022008 |
Fang-Rong Chang1, Tsong-Long Hwang, Yu-Liang Yang, Chia-En Li, Chin-Chung Wu, Hamad H Issa, Wen-Bin Hsieh, Yang-Chang Wu.
Abstract
A new clerodane diterpenoid 16-hydroxycleroda-13-ene-15,16-olide-3-one (1) was isolated from the bark of Polyalthia longifolia var. pendula, along with 23 known compounds and phytosteroids. Among these compounds, 5 - 7, 10, and 24 were obtained for the first time from the family Annonaceae . The structures of the isolated compounds were determined by mass and spectroscopic analysis. The clerodane diterpenoids, 2 - 4, showed significant cytotoxicity towards Hep G2 and Hep 3B hepatoma cell lines. Furthermore, compound 5 exhibited potent anti-inflammatory activity towards formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide generation by neutrophils with IC50 = 0.60 +/- 0.09 microg/mL.Entities:
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Year: 2006 PMID： 17022008 DOI： 10.1055/s-2006-951691
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352