Literature DB >> 17020302

Synthesis of 3-(aryl)alkenyl-beta-lactams by an efficient application of olefin cross-metathesis on solid support.

Sebastian A Testero1, Ernesto G Mata.   

Abstract

[reaction: see text] An efficient cross-metathesis on solid support for the synthesis of beta-lactam analogues of cholesterol absorption inhibitors is described. The applied strategy allows the introduction of diversity in positions 3 and 4 of the beta-lactam ring with excellent 3,4-trans selectivity and complete E selectivity at the C-3 side chain.

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Year:  2006        PMID： 17020302     DOI： 10.1021/ol061786u

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Efficient alkene synthesis on solid support using the Julia-Kocienski coupling.

Authors:  Dora B Boggián; Ernesto G Mata
Journal:  Mol Divers       Date:  2010-04-17       Impact factor: 2.943

2.  Synthesis of 3-aryl-1,2,4-benzotriazines via intramolecular cyclization of solid-supported o-hydrazidoanilines.

Authors:  Edwar Cortés; Luciana Méndez; Ernesto G Mata; Rodrigo Abonia; Jairo Quiroga; Braulio Insuasty
Journal:  Mol Divers       Date:  2012-10-10       Impact factor: 3.364

3.  Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives.

Authors:  Luciana Méndez; Andrés A Poeylaut-Palena; Ernesto G Mata
Journal:  Molecules       Date:  2018-05-16       Impact factor: 4.411
  3 in total

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