Literature DB >> 23054533

Synthesis of 3-aryl-1,2,4-benzotriazines via intramolecular cyclization of solid-supported o-hydrazidoanilines.

Edwar Cortés1, Luciana Méndez, Ernesto G Mata, Rodrigo Abonia, Jairo Quiroga, Braulio Insuasty.   

Abstract

An efficient solid-phase protocol for the rapid generation of libraries of biologically promising 1,2,4-benzotriazines, including amino acid-derived components, is described.

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Year:  2012        PMID： 23054533     DOI： 10.1007/s11030-012-9400-3

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   3.364


  31 in total

1.  Spiro[1,2,4-benzotriazine-3(4H),4'-(1'-substituted)piperidines] and related compounds as ligands for sigma receptors.

Authors:  Federica Novelli; Fabio Sparatore
Journal:  Farmaco       Date:  2002-11

2.  The synthesis of 3-substituted 6-aryl-3 H-benzo[a][1,2,3]triazinones using polymer-bound triazenes.

Authors:  Carmen Gil; Anja Schwögler; Stefan Bräse
Journal:  J Comb Chem       Date:  2004 Jan-Feb

3.  Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors.

Authors:  Glenn Noronha; Kathy Barrett; Jianguo Cao; Elena Dneprovskaia; Richard Fine; Xianchang Gong; Colleen Gritzen; John Hood; Xinshan Kang; Boris Klebansky; G Li; W Liao; Dan Lohse; Chi Ching Mak; Andrew McPherson; Moorthy S S Palanki; Ved P Pathak; Joel Renick; Richard Soll; Ute Splittgerber; Wolfgang Wrasidlo; Binqi Zeng; Ningning Zhao; Y Zhou
Journal:  Bioorg Med Chem Lett       Date:  2006-08-22       Impact factor: 2.823

4.  Cross metathesis on solid support. Novel strategy for the generation of beta-lactam libraries based on a versatile and multidetachable olefin linker.

Authors:  Andrés A Poeylaut-Palena; Ernesto G Mata
Journal:  J Comb Chem       Date:  2009 Sep-Oct

Review 5.  Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2008.

Authors:  Roland E Dolle; Bertrand Le Bourdonnec; Allan J Goodman; Guillermo A Morales; Craig J Thomas; Wei Zhang
Journal:  J Comb Chem       Date:  2009 Sep-Oct

6.  The influence of 1,2,4-benzotriazine derivatives on the apparent viscosity of human blood.

Authors:  H R Böhme; H Wilde
Journal:  Drug Des Deliv       Date:  1986-11

7.  Analogs of 3-amino-7-chloro-1,2,4-benzotriazine 1-oxide as antimalarial agents.

Authors:  J K Horner; D W Henry
Journal:  J Med Chem       Date:  1968-09       Impact factor: 7.446

8.  Synthesis of novel 1,2,5-trisubstituted benzimidazoles as potential antitumor agents.

Authors:  Rodrigo Abonia; Edwar Cortés; Braulio Insuasty; Jairo Quiroga; Manuel Nogueras; Justo Cobo
Journal:  Eur J Med Chem       Date:  2011-06-14       Impact factor: 6.514

9.  3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).

Authors:  T Fuchs; G Chowdhury; C L Barnes; K S Gates
Journal:  J Org Chem       Date:  2001-01-12       Impact factor: 4.354

10.  Gold catalysis on immobilized substrates: a heteroannulation approach to the solid-supported synthesis of indoles.

Authors:  Agustina La-Venia; Sebastián A Testero; Mirta P Mischne; Ernesto G Mata
Journal:  Org Biomol Chem       Date:  2012-02-14       Impact factor: 3.876
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