Literature DB >> 17020146

Toxicological mechanisms of Aconitum alkaloids.

M Fu1, M Wu, Y Qiao, Z Wang.   

Abstract

The toxic effects of Aconitum alkaloids are known to affect mainly the central nervous system, heart and muscle tissues. Their toxicological mechanisms may involve interaction with voltage-dependent Na+ channels, modulation of neurotransmitter release and related receptors, promotion of lipid peroxidation and induction of cell apoptosis in heart, liver or other organs. Of them, the mechanism of interaction with voltage-dependent Na+ channels is quite well known, but the other factors are still unclear, and need to be further studied. This review focuses on the toxicological mechanisms of Aconitum alkaloids.

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Year:  2006        PMID： 17020146

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  15 in total

1.  Hydroxylation Metabolisms of Crassicauline A in Rats Under Toxic Dose.

Authors:  Xue Fan; Shan-Shan Yin; Xue-Jing Li; Kui Yang; Liang Xu; Ke Lan
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2017-10       Impact factor: 2.441

2.  Overdose effect of aconite containing Ayurvedic Medicine ('Mahashankha Vati').

Authors:  Ashok Kumar Panda; Saroj Kumar Debnath
Journal:  Int J Ayurveda Res       Date:  2010-07

3.  Structure-activity relationships and the cytotoxic effects of novel diterpenoid alkaloid derivatives against A549 human lung carcinoma cells.

Authors:  Koji Wada; Masaharu Hazawa; Kenji Takahashi; Takao Mori; Norio Kawahara; Ikuo Kashiwakura
Journal:  J Nat Med       Date:  2010-08-14       Impact factor: 2.343

4.  Structure-activity relationships between the Aconitum C20-diterpenoid alkaloid derivatives and the growth suppressive activities of Non-Hodgkin's lymphoma Raji cells and human hematopoietic stem/progenitor cells.

Authors:  Masaharu Hazawa; Kenji Takahashi; Koji Wada; Takao Mori; Norio Kawahara; Ikuo Kashiwakura
Journal:  Invest New Drugs       Date:  2009-09-26       Impact factor: 3.850

5.  Hematological and Histopathological Effects of Subacute Aconitine Poisoning in Mouse.

Authors:  Hao Lu; Li Mei; Ziyu Guo; Kexin Wu; Yunhao Zhang; Shiyu Tang; Yiru Zhu; Baoyu Zhao
Journal:  Front Vet Sci       Date:  2022-04-05

6.  Tissue Accumulations of Toxic Aconitum Alkaloids after Short-Term and Long-Term Oral Administrations of Clinically Used Radix Aconiti Lateralis Preparations in Rats.

Authors:  Xiaoyu Ji; Mengbi Yang; Ka Hang Or; Wan Sze Yim; Zhong Zuo
Journal:  Toxins (Basel)       Date:  2019-06-18       Impact factor: 4.546

7.  Use of medicinal plants for headache, and their potential implication in medication-overuse headache: Evidence from a population-based study in Nepal.

Authors:  Elise Øien Sørnes; Ajay Risal; Kedar Manandhar; Hallie Thomas; Timothy J Steiner; Mattias Linde
Journal:  Cephalalgia       Date:  2021-01-12       Impact factor: 6.292

8.  Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5.

Authors:  Ling Ye; Xiao-Shan Yang; Lin-Lin Lu; Wei-Ying Chen; Shan Zeng; Tong-Meng Yan; Ling-Na Dong; Xiao-Juan Peng; Jian Shi; Zhong-Qiu Liu
Journal:  Evid Based Complement Alternat Med       Date:  2013-06-23       Impact factor: 2.629

9.  Toxic Constituents Index: A Toxicity-Calibrated Quantitative Evaluation Approach for the Precise Toxicity Prediction of the Hypertoxic Phytomedicine-Aconite.

Authors:  Ding-Kun Zhang; Rui-Sheng Li; Xue Han; Chun-Yu Li; Zhi-Hao Zhao; Hai-Zhu Zhang; Ming Yang; Jia-Bo Wang; Xiao-He Xiao
Journal:  Front Pharmacol       Date:  2016-06-17       Impact factor: 5.810

10.  Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.

Authors:  Fu Peng; Nan Zhang; Chunting Wang; Xiaoyun Wang; Wei Huang; Cheng Peng; Gu He; Bo Han
Journal:  Cell Prolif       Date:  2019-10-27       Impact factor: 6.831
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