Literature DB >> 17017527

Nicotine induces brain CYP enzymes: relevance to Parkinson's disease.

S Miksys1, R F Tyndale.   

Abstract

Brain expression of cytochromes P450 2B6, 2D6 and 2E1 is higher in smokers, and is induced by nicotine in animals. These enzymes can metabolize many of the neurotoxins associated with Parkinson's disease. Since smoking is known to be protective against Parkinson's disease, we hypothesise that nicotine-induced elevation of brain CYPs in smokers may contribute to neuroprotection against Parkinson's disease. This supports the therapeutic use of nicotine to delay the progress of this disease.

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Year:  2006        PMID： 17017527     DOI： 10.1007/978-3-211-45295-0_28

Source DB:  PubMed          Journal:  J Neural Transm Suppl        ISSN： 0303-6995


  24 in total

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8.  Potential role of CYP2D6 in the central nervous system.

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9.  Evidence for gender-specific transcriptional profiles of nigral dopamine neurons in Parkinson disease.

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10.  Monocrotophos Induces the Expression of Xenobiotic Metabolizing Cytochrome P450s (CYP2C8 and CYP3A4) and Neurotoxicity in Human Brain Cells.

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