D A Lawlor1, G Davey Smith, H Clark, D A Leon. 1. Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK. d.a.lawlor@bristol.ac.uk
Abstract
AIMS/HYPOTHESIS: The aim of this study was to examine the associations of birthweight, gestational age and childhood BMI (assessed at a mean age of 5 years) with a self-report of a doctor diagnosis of diabetes in middle age. METHODS: We studied a birth cohort of 5,793 individuals who were born between 1950 and 1956 in Aberdeen, Scotland, and who responded to a questionnaire administered in 2000. RESULTS: Birthweight and gestational age were inversely associated with diabetes. These associations remained with additional adjustment for indicators of childhood and adult socioeconomic position, maternal complications of pregnancy, adult smoking, adult BMI and simultaneous adjustment for each other: the adjusted odds ratio per unit increase in birthweight z score was 0.73 (95% CI 0.60-0.88), the odds ratio per week increase in gestational age was 0.91 (95% CI 0.82-1.00) and odds ratio for preterm birth was 2.04 (94% CI 1.18-3.53). The positive association of childhood BMI with diabetes was attenuated on adjustment for adult BMI. CONCLUSIONS/ INTERPRETATION: In this population, who were born in the 1950s, poor intrauterine growth and preterm birth are associated with an increased risk of diabetes.
AIMS/HYPOTHESIS: The aim of this study was to examine the associations of birthweight, gestational age and childhood BMI (assessed at a mean age of 5 years) with a self-report of a doctor diagnosis of diabetes in middle age. METHODS: We studied a birth cohort of 5,793 individuals who were born between 1950 and 1956 in Aberdeen, Scotland, and who responded to a questionnaire administered in 2000. RESULTS: Birthweight and gestational age were inversely associated with diabetes. These associations remained with additional adjustment for indicators of childhood and adult socioeconomic position, maternal complications of pregnancy, adult smoking, adult BMI and simultaneous adjustment for each other: the adjusted odds ratio per unit increase in birthweight z score was 0.73 (95% CI 0.60-0.88), the odds ratio per week increase in gestational age was 0.91 (95% CI 0.82-1.00) and odds ratio for preterm birth was 2.04 (94% CI 1.18-3.53). The positive association of childhood BMI with diabetes was attenuated on adjustment for adult BMI. CONCLUSIONS/ INTERPRETATION: In this population, who were born in the 1950s, poor intrauterine growth and preterm birth are associated with an increased risk of diabetes.
Authors: Debbie A Lawlor; G David Batty; Susan M B Morton; Heather Clark; Sally Macintyre; David A Leon Journal: Am J Public Health Date: 2005-07 Impact factor: 9.308
Authors: A Fagot-Campagna; D J Pettitt; M M Engelgau; N R Burrows; L S Geiss; R Valdez; G L Beckles; J Saaddine; E W Gregg; D F Williamson; K M Narayan Journal: J Pediatr Date: 2000-05 Impact factor: 4.406
Authors: G David Batty; Susan M B Morton; Doris Campbell; Heather Clark; George Davey Smith; Marison Hall; Sally Macintyre; David A Leon Journal: Paediatr Perinat Epidemiol Date: 2004-05 Impact factor: 3.980
Authors: Paul L Hofman; Fiona Regan; Wendy E Jackson; Craig Jefferies; David B Knight; Elizabeth M Robinson; Wayne S Cutfield Journal: N Engl J Med Date: 2004-11-18 Impact factor: 91.245
Authors: Edwina H Yeung; Cuilin Zhang; Germaine M Buck Louis; Walter C Willett; Frank B Hu Journal: Diabetes Care Date: 2010-03-09 Impact factor: 17.152
Authors: Ravi Nistala; Melvin R Hayden; Vincent G Demarco; Erik J Henriksen; Daniel T Lackland; James R Sowers Journal: Cardiorenal Med Date: 2011-10-12 Impact factor: 2.041
Authors: Tian Hu; David R Jacobs; Alan R Sinaiko; Lydia A Bazzano; Trudy L Burns; Stephen R Daniels; Terry Dwyer; Nina Hutri-Kähönen; Markus Juonala; Kari A Murdy; Ronald J Prineas; Olli T Raitakari; Elaine M Urbina; Alison Venn; Jessica G Woo; Julia Steinberger Journal: Diabetes Care Date: 2020-09-01 Impact factor: 19.112
Authors: Petteri Hovi; Eero Kajantie; Pasi Soininen; Antti J Kangas; Anna-Liisa Järvenpää; Sture Andersson; Johan G Eriksson; Mika Ala-Korpela; Karoliina Wehkalampi Journal: Lipids Health Dis Date: 2013-04-30 Impact factor: 3.876