BACKGROUND: The purpose of this study was to establish a cohort of symptomatic twins with Scheuermann kyphosis to provide estimates of prevalence, concordance, odds ratio, and heritability. These estimates indicate to what extent genetic factors contribute to the etiology of this disease. METHODS: The Odense-based Danish Twin Registry is unique in that it contains data on all 73,000 twin pairs born in Denmark over the last 130 years. For the present study, all 46,418 twins born from 1931 through 1982 received a seventeen-page questionnaire, in which one question was "Have you been diagnosed with Scheuermann disease by a doctor"? The prevalence of self-reported Scheuermann disease was calculated, with the total number of answers used as the general population. Pairwise and probandwise concordance, odds ratio, tetrachoric correlations, and heritability were calculated. RESULTS: We found that the overall prevalence of Scheuermann disease was 2.8%, with a prevalence of 2.1% among women and 3.6% among men (p < 0.0001). The pairwise concordance for monozygotic twins was 0.19 compared with 0.07 for dizygotic twins. The probandwise concordance was 0.31 for monozygotic twins and 0.13 for dizygotic twins. The odds ratios were 32.92 and 6.25 in the monozygotic and dizygotic twins, respectively. These differences were significant (p < 0.01). Heritability was 74%. CONCLUSIONS: In a large cohort of twins that included almost 35,000 individuals, the self-reported overall prevalence of Scheuermann disease was 2.8% and the male-to-female ratio was close to 2:1. Because the pairwise and probandwise concordance and the odds ratio were two to three times higher in monozygotic than in dizygotic twins and the heritability was high, we concluded that there is a major genetic contribution to the etiology of Scheuermann disease.
BACKGROUND: The purpose of this study was to establish a cohort of symptomatic twins with Scheuermann kyphosis to provide estimates of prevalence, concordance, odds ratio, and heritability. These estimates indicate to what extent genetic factors contribute to the etiology of this disease. METHODS: The Odense-based Danish Twin Registry is unique in that it contains data on all 73,000 twin pairs born in Denmark over the last 130 years. For the present study, all 46,418 twins born from 1931 through 1982 received a seventeen-page questionnaire, in which one question was "Have you been diagnosed with Scheuermann disease by a doctor"? The prevalence of self-reported Scheuermann disease was calculated, with the total number of answers used as the general population. Pairwise and probandwise concordance, odds ratio, tetrachoric correlations, and heritability were calculated. RESULTS: We found that the overall prevalence of Scheuermann disease was 2.8%, with a prevalence of 2.1% among women and 3.6% among men (p < 0.0001). The pairwise concordance for monozygotic twins was 0.19 compared with 0.07 for dizygotic twins. The probandwise concordance was 0.31 for monozygotic twins and 0.13 for dizygotic twins. The odds ratios were 32.92 and 6.25 in the monozygotic and dizygotic twins, respectively. These differences were significant (p < 0.01). Heritability was 74%. CONCLUSIONS: In a large cohort of twins that included almost 35,000 individuals, the self-reported overall prevalence of Scheuermann disease was 2.8% and the male-to-female ratio was close to 2:1. Because the pairwise and probandwise concordance and the odds ratio were two to three times higher in monozygotic than in dizygotic twins and the heritability was high, we concluded that there is a major genetic contribution to the etiology of Scheuermann disease.
Authors: Subhash C Juneja; Alin Vonica; Caroline Zeiss; Kimberly Lezon-Geyda; Bogdan Yatsula; David R Sell; Vincent M Monnier; Sharon Lin; Thomas Ardito; David Eyre; David Reynolds; Zhenqiang Yao; Hani A Awad; Hongbo Yu; Michael Wilson; Sylvie Honnons; Brendan F Boyce; Lianping Xing; Yi Zhang; Archibald S Perkins Journal: Bone Date: 2013-12-04 Impact factor: 4.398
Authors: Matthew A Halanski; Blake Hildahl; Laura A Amundson; Ellen Leiferman; Annette Gendron-Fitzpatrick; Rajeev Chaudhary; Heather M Hartwig-Stokes; Ronald McCabe; Rachel Lenhart; Matthew Chin; Jennifer Birstler; Thomas D Crenshaw Journal: J Bone Joint Surg Am Date: 2018-03-07 Impact factor: 5.284
Authors: E Fotiadis; E Kenanidis; E Samoladas; A Christodoulou; P Akritopoulos; K Akritopoulou Journal: Eur Spine J Date: 2008-02-27 Impact factor: 3.134
Authors: Ling Oei; Felisia Ly; Salih El Saddy; Ater A Makurthou; Albert Hofman; Frank J A van Rooij; André G Uitterlinden; M Carola Zillikens; Fernando Rivadeneira; Edwin H G Oei Journal: Quant Imaging Med Surg Date: 2013-10