Literature DB >> 17013386

Rad4-Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repair.

Feng Gong1, Deirdre Fahy, Michael J Smerdon.   

Abstract

Chromatin rearrangement occurs during nucleotide excision repair (NER). Here we show that Snf6 and Snf5, two subunits of the SWI/SNF chromatin-remodeling complex in Saccharomyces cerevisiae, copurify with the NER damage-recognition heterodimer Rad4-Rad23. This interaction between SWI/SNF and Rad4-Rad23 is stimulated by UV irradiation. We demonstrate that NER in the transcriptionally silent, nucleosome-loaded HML locus is reduced in yeast cells lacking functional SWI/SNF. In addition, using a restriction enzyme accessibility assay, we observed UV-induced nucleosome rearrangement at the silent HML locus. Notably, this rearrangement is markedly attenuated when SWI/SNF is inactivated. These results indicate that the SWI/SNF chromatin-remodeling complex is recruited to DNA lesions by damage-recognition proteins to increase DNA accessibility for NER in chromatin.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17013386     DOI： 10.1038/nsmb1152

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  72 in total

Review 1.  Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling.

Authors:  Gang G Wang; C David Allis; Ping Chi
Journal:  Trends Mol Med       Date:  2007-09-05       Impact factor: 11.951

2.  Pervasive sex-linked effects on transcription regulation as revealed by expression quantitative trait loci mapping in lake whitefish species pairs (Coregonus sp., Salmonidae).

Authors:  N Derome; B Bougas; S M Rogers; A R Whiteley; A Labbe; J Laroche; L Bernatchez
Journal:  Genetics       Date:  2008-07-27       Impact factor: 4.562

Review 3.  Nucleotide excision repair in eukaryotes.

Authors:  Orlando D Schärer
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-10-01       Impact factor: 10.005

4.  Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.

Authors:  Xiaofeng Wang; Jeffrey R Haswell; Charles W M Roberts
Journal:  Clin Cancer Res       Date:  2013-10-11       Impact factor: 12.531

5.  Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair.

Authors:  Danielle Tatum; Wentao Li; Margaret Placer; Shisheng Li
Journal:  J Biol Chem       Date:  2011-07-07       Impact factor: 5.157

6.  Activity of FEN1 endonuclease on nucleosome substrates is dependent upon DNA sequence but not flap orientation.

Authors:  Indu Jagannathan; Sharon Pepenella; Jeffrey J Hayes
Journal:  J Biol Chem       Date:  2011-03-31       Impact factor: 5.157

7.  Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.

Authors:  Danielle Tatum; Shisheng Li
Journal:  J Biol Chem       Date:  2011-04-01       Impact factor: 5.157

Review 8.  Determinants and dynamics of genome accessibility.

Authors:  Oliver Bell; Vijay K Tiwari; Nicolas H Thomä; Dirk Schübeler
Journal:  Nat Rev Genet       Date:  2011-07-12       Impact factor: 53.242

9.  Photoprotective Role of Photolyase-Interacting RAD23 and Its Pleiotropic Effect on the Insect-Pathogenic Fungus Beauveria bassiana.

Authors:  Ding-Yi Wang; Ya-Ni Mou; Sen-Miao Tong; Sheng-Hua Ying; Ming-Guang Feng
Journal:  Appl Environ Microbiol       Date:  2020-05-19       Impact factor: 4.792

10.  A cassette of N-terminal amino acids of histone H2B are required for efficient cell survival, DNA repair and Swi/Snf binding in UV irradiated yeast.

Authors:  Ronita Nag; McKenna Kyriss; John W Smerdon; John J Wyrick; Michael J Smerdon
Journal:  Nucleic Acids Res       Date:  2009-12-09       Impact factor: 16.971
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.