Literature DB >> 17012190

A small-scale concept-based laboratory component: the best of both worlds.

Dina Gould Halme1, Julia Khodor, Rudolph Mitchell, Graham C Walker.   

Abstract

In this article, we describe an exploratory study of a small-scale, concept-driven, voluntary laboratory component of Introductory Biology at the Massachusetts Institute of Technology. We wished to investigate whether students' attitudes toward biology and their understanding of basic biological principles would improve through concept-based learning in a laboratory environment. With these goals in mind, and using our Biology Concept Framework as a guide, we designed laboratory exercises to connect topics from the lecture portion of the course and highlight key concepts. We also strove to make abstract concepts tangible, encourage learning in nonlecture format, expose the students to scientific method in action, and convey the excitement of performing experiments. Our initial small-scale assessments indicate participation in the laboratory component, which featured both hands-on and minds-on components, improved student learning and retention of basic biological concepts. Further investigation will focus on improving the balance between the minds-on concept-based learning and the hands-on experimental component of the laboratory.

Mesh:

Year:  2006        PMID: 17012190      PMCID: PMC1635131          DOI: 10.1187/cbe.05-02-0065

Source DB:  PubMed          Journal:  CBE Life Sci Educ        ISSN: 1931-7913            Impact factor:   3.325


  6 in total

1.  Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme.

Authors:  O Kabil; S Toaka; R LoBrutto; R Shoemaker; R Banerjee
Journal:  J Biol Chem       Date:  2001-02-26       Impact factor: 5.157

Review 2.  A hierarchical biology concept framework: a tool for course design.

Authors:  Julia Khodor; Dina Gould Halme; Graham C Walker
Journal:  Cell Biol Educ       Date:  2004

3.  Mutations in the regulatory domain of cystathionine beta synthase can functionally suppress patient-derived mutations in cis.

Authors:  X Shan; R L Dunbrack; S A Christopher; W D Kruger
Journal:  Hum Mol Genet       Date:  2001-03-15       Impact factor: 6.150

4.  Domain architecture of the heme-independent yeast cystathionine beta-synthase provides insights into mechanisms of catalysis and regulation.

Authors:  K H Jhee; P McPhie; E W Miles
Journal:  Biochemistry       Date:  2000-08-29       Impact factor: 3.162

5.  A yeast assay for functional detection of mutations in the human cystathionine beta-synthase gene.

Authors:  W D Kruger; D R Cox
Journal:  Hum Mol Genet       Date:  1995-07       Impact factor: 6.150

6.  A yeast system for expression of human cystathionine beta-synthase: structural and functional conservation of the human and yeast genes.

Authors:  W D Kruger; D R Cox
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-05       Impact factor: 11.205

  6 in total
  8 in total

1.  A semester-long student-directed research project involving enzyme immunoassay: appropriate for immunology, endocrinology, or neuroscience courses.

Authors:  Sharon Ramos Goyette; Jane DeLuca
Journal:  CBE Life Sci Educ       Date:  2007       Impact factor: 3.325

2.  Aligning goals, assessments, and activities: an approach to teaching PCR and gel electrophoresis.

Authors:  Allison R Phillips; Amber L Robertson; Janet Batzli; Michelle Harris; Sarah Miller
Journal:  CBE Life Sci Educ       Date:  2008       Impact factor: 3.325

3.  Effectiveness of a cloning and sequencing exercise on student learning with subsequent publication in the National Center for Biotechnology Information GenBank.

Authors:  Joann M Lau; David L Robinson
Journal:  CBE Life Sci Educ       Date:  2009       Impact factor: 3.325

4.  A Hybrid Teaching Method for Undergraduate Biomechanics Lab.

Authors:  Ruth Ochia
Journal:  Biomed Eng Educ       Date:  2020-10-13

5.  Implementation of a project-based molecular biology laboratory emphasizing protein structure-function relationships in a large introductory biology laboratory course.

Authors:  Daniel J Treacy; Saumya M Sankaran; Susannah Gordon-Messer; Danielle Saly; Rebecca Miller; Stefan R Isaac; Melissa S Kosinski-Collins
Journal:  CBE Life Sci Educ       Date:  2011       Impact factor: 3.325

6.  A comprehensive faculty, staff, and student training program enhances student perceptions of a course-based research experience at a two-year institution.

Authors:  Thomas D Wolkow; Lisa T Durrenberger; Michael A Maynard; Kylie K Harrall; Lisa M Hines
Journal:  CBE Life Sci Educ       Date:  2014       Impact factor: 3.325

7.  Adapting a Human Physiology Teaching Laboratory to the At-Home Education Setting.

Authors:  Victor Ong; Stanley Yamashiro
Journal:  Biomed Eng Educ       Date:  2021-07-21

8.  Human umbilical cord blood plasma as an alternative to animal sera for mesenchymal stromal cells in vitro expansion - A multicomponent metabolomic analysis.

Authors:  A R Caseiro; G Ivanova; S S Pedrosa; M V Branquinho; P Georgieva; P P Barbosa; J D Santos; R Magalhães; P Teixeira; T Pereira; A C Maurício
Journal:  PLoS One       Date:  2018-10-10       Impact factor: 3.240

  8 in total

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