OBJECTIVE: Cellular and subcellular localization of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) in uterine leiomyomas. DESIGN: Retrospective study. SETTING: University of La Laguna (ULL) and Canary University Hospital (HUC). PATIENT(S): Premenopausal and postmenopausal women with uterine leiomyomas. INTERVENTION(S): Hysterectomy and myomectomy. RESULT(S): Estrogen receptor alpha was only present in smooth muscle cells with variation in the subcellular location in different leiomyomas. Estrogen receptor beta was widely distributed in smooth muscle, endothelial, and connective tissue cells with nuclear location in all cases studied; variations were only found in the muscle cells for this receptor. CONCLUSION(S): Estrogens operate in leiomyoma smooth muscle cells through different receptors, alpha and beta. However they only act through the ERbeta in endothelial and connective cells.
OBJECTIVE: Cellular and subcellular localization of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) in uterine leiomyomas. DESIGN: Retrospective study. SETTING: University of La Laguna (ULL) and Canary University Hospital (HUC). PATIENT(S): Premenopausal and postmenopausal women with uterine leiomyomas. INTERVENTION(S): Hysterectomy and myomectomy. RESULT(S): Estrogen receptor alpha was only present in smooth muscle cells with variation in the subcellular location in different leiomyomas. Estrogen receptor beta was widely distributed in smooth muscle, endothelial, and connective tissue cells with nuclear location in all cases studied; variations were only found in the muscle cells for this receptor. CONCLUSION(S): Estrogens operate in leiomyoma smooth muscle cells through different receptors, alpha and beta. However they only act through the ERbeta in endothelial and connective cells.
Authors: Bruce R Carr; Elizabeth A Stewart; David F Archer; Ayman Al-Hendy; Linda Bradley; Nelson B Watts; Michael P Diamond; Jingjing Gao; Charlotte D Owens; Kristof Chwalisz; W Rachel Duan; Ahmed M Soliman; Matthew B Dufek; James A Simon Journal: Obstet Gynecol Date: 2018-11 Impact factor: 7.661
Authors: Kamila Wojtowicz; Tomasz Góra; Paweł Guzik; Magdalena Harpula; Paweł Chechliński; Ewelina Wolak; Aleksandra Stryjkowska-Góra Journal: J Ultrason Date: 2022-04-27
Authors: Alexandra M Binder; Leah T Stiemsma; Kristen Keller; Sanne D van Otterdijk; Verónica Mericq; Ana Pereira; José L Santos; John Shepherd; Karin B Michels Journal: Clin Epigenetics Date: 2018-10-04 Impact factor: 6.551