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Literature DB >> 26715264

Association of estrogen and progesterone receptor gene polymorphisms and their respective hormones in uterine leiomyomas.

M Veronica¹, Altaf Ali¹, A Venkateshwari², D Mamata³, Pratibha Nallari⁴.

Abstract

The steroid hormones estradiol and progesterone play an important role in the pathophysiology of fibroids that occurs in 20-25 % of women in the reproductive age. Our study examines the risk imposed by estrogen and progesterone plasma levels in correlation with the ERβ (-13950T/C) and PGR (+331G/A) receptor gene polymorphisms. The study population included 296 individuals (146 UL cases and 150 female controls). Hormonal levels were estimated by ELISA and genotyping was carried out by PCR-RFLP analysis, and the obtained results were statistically analyzed. Estrogen levels were found to be high in cases with the "TC" genotype of ERβ receptor polymorphism compared to controls, whereas individuals with "GA" and "AA" genotype of PGR receptor polymorphism showed high progesterone levels for cases when compared to controls. The TC genotype of the ERβ receptor polymorphism and the GA and AA genotypes of the PGR receptor polymorphism and their respective hormonal levels can be developed as markers in the prediction of uterine fibroids.

Entities: Chemical Disease Gene Mutation Species

Keywords: Estrogen; Infertility; Progesterone; Reproduction; Uterine leiomyomas

Mesh：

Substances：

Year: 2015 PMID： 26715264 DOI： 10.1007/s13277-015-4711-5

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

21 in total

1. Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women.

Authors: Michael N Passarelli; Amanda I Phipps; John D Potter; Karen W Makar; Anna E Coghill; Karen J Wernli; Emily White; Andrew T Chan; Carolyn M Hutter; Ulrike Peters; Polly A Newcomb
Journal: Cancer Res Date: 2012-11-13 Impact factor: 12.701

2. A functional polymorphism in the progesterone receptor gene is associated with an increase in breast cancer risk.

Authors: Immaculata De Vivo; Susan E Hankinson; Graham A Colditz; David J Hunter
Journal: Cancer Res Date: 2003-09-01 Impact factor: 12.701

3. Estrogen receptor beta gene polymorphisms and susceptibility to uterine fibroids.

Authors: Claudia Fischer; Ingolf Juhasz-Boess; Claus Lattrich; Olaf Ortmann; Oliver Treeck
Journal: Gynecol Endocrinol Date: 2010-01 Impact factor: 2.260

4. Estrogen receptor beta polymorphism is associated with prostate cancer risk.

Authors: Camilla Thellenberg-Karlsson; Sara Lindström; Beatrice Malmer; Fredrik Wiklund; Katarina Augustsson-Bälter; Hans-Olov Adami; Par Stattin; Maria Nilsson; Karin Dahlman-Wright; Jan-Ake Gustafsson; Henrik Grönberg
Journal: Clin Cancer Res Date: 2006-03-15 Impact factor: 12.531

5. Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse.

Authors: Huey-Yi Chen; Lei Wan; Ya-Wen Chung; Wei-Chi Chen; Fuu-Jen Tsai; Chang-Hai Tsai
Journal: Eur J Obstet Gynecol Reprod Biol Date: 2008-03-04 Impact factor: 2.435

6. Th1/Th2 cytokine gene polymorphisms in patients with uterine fibroid.

Authors: O Sosna; L Kolesár; A Slavčev; J Skibová; T Fait; M Mara; I Stříž; D Kužel
Journal: Folia Biol (Praha) Date: 2010 Impact factor: 0.906

7. Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis.

Authors: Sanjib Chaudhary; Aditya K Panda; Dipti Ranjan Mishra; Sandip K Mishra
Journal: PLoS One Date: 2013-01-22 Impact factor: 3.240

Association of estrogen and progesterone receptor gene polymorphisms and their respective hormones in uterine leiomyomas.

1. Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women.

2. A functional polymorphism in the progesterone receptor gene is associated with an increase in breast cancer risk.

3. Estrogen receptor beta gene polymorphisms and susceptibility to uterine fibroids.

4. Estrogen receptor beta polymorphism is associated with prostate cancer risk.

5. Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse.

6. Th1/Th2 cytokine gene polymorphisms in patients with uterine fibroid.

7. Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis.

Review 8. Etiology and pathogenesis of uterine leiomyomas: a review.

Review 9. Uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction.

Review 10. Uterine fibroids: current perspectives.

1. Analysis of estrogen and progesterone receptor gene polymorphisms in leiomyoma.

Review 2. Polymorphisms in sex steroid receptors: From gene sequence to behavior.

Review 3. Mitochondrial determinants of cancer health disparities.

4. Oestrogen receptor alpha PvuII polymorphism and uterine fibroid incidence in Caucasian women.