| Literature DB >> 17011161 |
Chien-Yu Wang1, Ming-Tsang Chiao1, Po-Jen Yen1, Wei-Chou Huang1, Chia-Chung Hou1, Shih-Chang Chien1, Kuo-Chen Yeh1, Wen-Ching Yang1, Lie-Fen Shyur2, Ning-Sun Yang3.
Abstract
Echinacea spp. are popularly used as an herbal medicine or food supplement for enhancing the immune system. This study shows that plant extracts from root [R] and stem plus leaf [S+L] tissues of E. purpurea exhibit opposite (enhancing vs inhibitory) modulatory effects on the expression of the CD83 marker in human dendritic cells (DCs), which are known as professional antigen-presenting cells. We developed a function-targeted DNA microarray system to characterize the effects of phytocompounds on human DCs. Down-regulation of mRNA expression of specific chemokines (e.g., CCL3 and CCL8) and their receptors (e.g., CCR1 and CCR9) was observed in [S+L]-treated DCs. Other chemokines and regulatory molecules (e.g., CCL4 and CCL2) involved in the c-Jun pathway were found to be up-regulated in [R]-treated DCs. This study, for the first time, demonstrates that E. purpurea extracts can modulate DC differentiation and expression of specific immune-related genes in DCs.Entities:
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Year: 2006 PMID： 17011161 DOI： 10.1016/j.ygeno.2006.08.011
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736