| Literature DB >> 17011048 |
Manoj Kumar1, Norman Putzki, Volker Limmroth, Ralph Remus, Monika Lindemann, Dietmar Knop, Norbert Mueller, Cornelia Hardt, Ernst Kreuzfelder, Hans Grosse-Wilde.
Abstract
Multiple sclerosis (MS) is an autoimmune disorder directed against self antigens of the central nervous system. CD4(+)CD25(+)FoxP3(+) regulatory T cell (T(reg)) mediated suppression is an essential mechanism of self-tolerance. We studied whether changes in the suppressive function of a mixture of CD25(high) and CD25(intemediate) expressing T(reg) cells in myelin basic protein (MBP)-induced proliferation occurred in untreated MS patients. Suppression of MBP-induced proliferation was observed in 13 out of 29 (45%) MS patients; this was significantly (p<0.05) less compared with 17 out of 19 (89%) healthy individuals. Relative T(reg) counts was significantly increased in MS patients (mean+/-S.D.; 20+/-8%) compared with healthy individuals (15+/-5%). These findings suggest that impaired T(reg) function may be involved in pathogenesis of MS.Entities:
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Year: 2006 PMID： 17011048 DOI： 10.1016/j.jneuroim.2006.08.003
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478