Literature DB >> 17008104

Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analog.

Ritu Aneja1, Surya N Vangapandu, Harish C Joshi.   

Abstract

We present here a novel semi-synthetic cyclic ether fluorinated noscapine analog (CEFNA) that shows potent antiproliferative and anticancer activity in both hormone-responsive (MCF-7) and hormone non-responsive (MDA-MB-231) breast cancer cells. Interestingly, it is also effective against MCF-7/Adr, an adriamycin-resistant variant of MCF-7 cells. Immunofluorescence experiments showed numerous micronuclei, indicative of apoptotic cell death triggered by this novel analog. Mechanistically, CEFNA exerts a strong antimitotic effect as revealed by cell-cycle studies that show a dose-dependent increase in G2/M population preceding a rising sub-G1 population, suggesting apoptosis.

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Year:  2006        PMID： 17008104     DOI： 10.1016/j.bmc.2006.09.012

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  15 in total

1.  Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathway.

Authors:  Bokyung Sung; Kwang Seok Ahn; Bharat B Aggarwal
Journal:  Cancer Res       Date:  2010-03-30       Impact factor: 12.701

2.  Molecular cycloencapsulation augments solubility and improves therapeutic index of brominated noscapine in prostate cancer cells.

Authors:  Jitender Madan; Bharat Baruah; Mulpuri Nagaraju; Mohamed O Abdalla; Clayton Yates; Timothy Turner; Vijay Rangari; Donald Hamelberg; Ritu Aneja
Journal:  Mol Pharm       Date:  2012-04-27       Impact factor: 4.939

Review 3.  Drugs that target dynamic microtubules: a new molecular perspective.

Authors:  Richard A Stanton; Kim M Gernert; James H Nettles; Ritu Aneja
Journal:  Med Res Rev       Date:  2011-03-04       Impact factor: 12.944

4.  Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluation.

Authors:  Ram Chandra Mishra; Prasanthi Karna; Sushma Reddy Gundala; Vaishali Pannu; Richard A Stanton; Kamlesh Kumar Gupta; M Hope Robinson; Manu Lopus; Leslie Wilson; Maged Henary; Ritu Aneja
Journal:  Biochem Pharmacol       Date:  2011-04-08       Impact factor: 5.858

5.  Rational design, synthesis and biological evaluations of amino-noscapine: a high affinity tubulin-binding noscapinoid.

Authors:  Pradeep K Naik; Biswa Prasun Chatterji; Surya N Vangapandu; Ritu Aneja; Ramesh Chandra; Srinivas Kanteveri; Harish C Joshi
Journal:  J Comput Aided Mol Des       Date:  2011-05-05       Impact factor: 3.686

6.  Noscapinoids with anti-cancer activity against human acute lymphoblastic leukemia cells (CEM): a three dimensional chemical space pharmacophore modeling and electronic feature analysis.

Authors:  Pradeep K Naik; Seneha Santoshi; Harish C Joshi
Journal:  J Mol Model       Date:  2011-04-27       Impact factor: 1.810

7.  (3R*,5'S*)-6,7-Dimeth-oxy-3-(4'-meth-oxy-6'-methyl-5',6',7',8'-tetra-hydro-1,3-dioxolo[4,5-g]isoquinolin-5'-yl)isobenzofuran-1(3H)-one (racemic α-noscapine).

Authors:  Jan von Langermann; Heike Lorenz; Oliver Boehm; Anke Flemming; Arne Bernsdorf; Martin Köckerling; Dieter Schinzer; Andreas Seidel-Morgenstern
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-02-10

8.  Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A.

Authors:  Jacob Kach; Nathan Sandbo; Jennifer La; Darcy Denner; Eleanor B Reed; Olga Akimova; Svetlana Koltsova; Sergei N Orlov; Nickolai O Dulin
Journal:  J Biol Chem       Date:  2014-02-03       Impact factor: 5.157

9.  CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism.

Authors:  Yunfan Yang; Jie Ran; Lei Sun; Xiaodong Sun; Youguang Luo; Bing Yan; Min Liu; Dengwen Li; Lei Zhang; Gang Bao; Jun Zhou
Journal:  Theranostics       Date:  2015-03-02       Impact factor: 11.556

10.  Rational design, synthesis, and biological evaluation of third generation α-noscapine analogues as potent tubulin binding anti-cancer agents.

Authors:  Naresh Kumar Manchukonda; Pradeep Kumar Naik; Seneha Santoshi; Manu Lopus; Silja Joseph; Balasubramanian Sridhar; Srinivas Kantevari
Journal:  PLoS One       Date:  2013-10-21       Impact factor: 3.240
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