Literature DB >> 1700698

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat.

R G Knowles1, M Merrett, M Salter, S Moncada.   

Abstract

Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation.

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Year:  1990        PMID： 1700698      PMCID： PMC1131810          DOI： 10.1042/bj2700833

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

1.  Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

Authors:  D S Bredt; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

2.  Kinetic characteristics of nitric oxide synthase from rat brain.

Authors:  R G Knowles; M Palacios; R M Palmer; S Moncada
Journal:  Biochem J       Date:  1990-07-01       Impact factor: 3.857

Review 3.  Preparation of isolated rat liver cells.

Authors:  P O Seglen
Journal:  Methods Cell Biol       Date:  1976       Impact factor: 1.441

4.  A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells.

Authors:  R M Palmer; S Moncada
Journal:  Biochem Biophys Res Commun       Date:  1989-01-16       Impact factor: 3.575

5.  Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.

Authors:  N S Kwon; C F Nathan; D J Stuehr
Journal:  J Biol Chem       Date:  1989-12-05       Impact factor: 5.157

6.  Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

Authors:  R G Knowles; M Palacios; R M Palmer; S Moncada
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

7.  Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.

Authors:  D Salvemini; G de Nucci; R J Gryglewski; J R Vane
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

8.  Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate.

Authors:  M A Marletta; P S Yoon; R Iyengar; C D Leaf; J S Wishnok
Journal:  Biochemistry       Date:  1988-11-29       Impact factor: 3.162

9.  Antiproliferative activity of gamma-interferon combined with lipopolysaccharide on murine adenocarcinoma: dependence on an L-arginine metabolism with production of nitrite and citrulline.

Authors:  M Lepoivre; H Boudbid; J F Petit
Journal:  Cancer Res       Date:  1989-04-15       Impact factor: 12.701

10.  Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment.

Authors:  D A Wagner; V R Young; S R Tannenbaum
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205
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  61 in total

1.  The effect of lymphatic blockage on the amount of endotoxin in portal circulation, nitric oxide synthesis, and the liver in dogs with peritonitis.

Authors:  O Güler; S Uğraş; M Aydin; F H Dilek; O N Dilek; M Karaayvaz
Journal:  Surg Today       Date:  1999       Impact factor: 2.549

2.  Induction and potential biological relevance of a Ca(2+)-independent nitric oxide synthase in the myocardium.

Authors:  R Schulz; E Nava; S Moncada
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

3.  Tissue injury caused by deposition of immune complexes is L-arginine dependent.

Authors:  M S Mulligan; J M Hevel; M A Marletta; P A Ward
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

4.  Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension.

Authors:  M P Pizcueta; J M Piqué; J Bosch; B J Whittle; S Moncada
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

5.  Sequential induction of nitric oxide synthase by Corynebacterium parvum in different organs of the mouse.

Authors:  D D Rees; F Q Cunha; J Assreuy; A G Herman; S Moncada
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739

6.  Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock.

Authors:  C Szabó; J A Mitchell; C Thiemermann; J R Vane
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739

7.  Group B Streptococcus and E. coli LPS-induced NO-dependent hyporesponsiveness to noradrenaline in isolated intrapulmonary arteries of neonatal piglets.

Authors:  E Villamor; F Pérez-Vizcaíno; T Ruiz; J C Leza; M Moro; J Tamargo
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

8.  Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels.

Authors:  A M Genaro; S Hortelano; A Alvarez; C Martínez; L Boscá
Journal:  J Clin Invest       Date:  1995-04       Impact factor: 14.808

9.  Inhibition of hepatic gluconeogenesis by nitric oxide: a comparison with endotoxic shock.

Authors:  R A Horton; E D Ceppi; R G Knowles; M A Titheradge
Journal:  Biochem J       Date:  1994-05-01       Impact factor: 3.857

10.  Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models.

Authors:  Sevil Tanas; Fehmi Odabasoglu; Zekai Halici; Ahmet Cakir; Hayati Aygun; Ali Aslan; Halis Suleyman
Journal:  J Nat Med       Date:  2009-10-15       Impact factor: 2.343
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