Literature DB >> 2912454

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells.

R M Palmer1, S Moncada.   

Abstract

An enzyme in homogenates of porcine vascular endothelial cells forms L-citrulline from L-arginine. This enzyme is soluble and NADPH-dependent. In addition, the enzyme is inhibited by NG-monomethyl-L-arginine, suggesting that it is involved in the formation of nitric oxide by vascular endothelial cells.

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Year:  1989        PMID： 2912454     DOI： 10.1016/s0006-291x(89)80219-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  122 in total

1.  Essential role of L-arginine uptake and protein tyrosine kinase activity for NO-dependent vasorelaxation induced by stretch, isometric tension and cyclic AMP in rat pulmonary arteries.

Authors:  D Hucks; N M Khan; J P Ward
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

2.  Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

Authors:  K Nishida; D G Harrison; J P Navas; A A Fisher; S P Dockery; M Uematsu; R M Nerem; R W Alexander; T J Murphy
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

3.  A perfusion system for the long term study of macrophage activation.

Authors:  J Assreuy; S Moncada
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

4.  Cyclic GMP stimulation by vasopressin in LLC-PK1 kidney epithelial cells is L-arginine-dependent.

Authors:  H Schröder; K Schrör
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-10       Impact factor: 3.000

5.  Effects of pyrimidines on the guinea-pig coronary vasculature.

Authors:  A J Vials; G Burnstock
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

Review 6.  Endothelium-derived nitric oxide: pharmacology and relationship to the actions of organic nitrate esters.

Authors:  L J Ignarro
Journal:  Pharm Res       Date:  1989-08       Impact factor: 4.200

7.  Interactions of nitric oxide synthase inhibitors and dexamethasone with alpha-adrenoceptor-mediated responses in rat aorta.

Authors:  A S Adeagbo; C R Triggle
Journal:  Br J Pharmacol       Date:  1993-06       Impact factor: 8.739

8.  Counteraction of the rapid tolerance to 8-OH-DPAT-induced corticosterone secretion in rats by activation of the GABAA receptor-chloride channel complex.

Authors:  D Kelder; S B Ross
Journal:  Br J Pharmacol       Date:  1993-05       Impact factor: 8.739

9.  Impairment of pulmonary-artery endothelium-dependent relaxation in chronic obstructive lung disease is not due to dysfunction of endothelial cell membrane receptors nor to L-arginine deficiency.

Authors:  A T Dinh-Xuan; J Pepke-Zaba; A Y Butt; G Cremona; T W Higenbottam
Journal:  Br J Pharmacol       Date:  1993-06       Impact factor: 8.739

10.  Endothelin-1 in the rabbit: interactions with cyclo-oxygenase and NO-synthase products.

Authors:  M E Rogerson; H S Cairns; L D Fairbanks; J Westwick; G H Neild
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739
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