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Literature DB >> 1700693

Comparative studies on tat mutants of three primate lentiviruses.

R Shibata¹, H Sakai, K Ogawa, A Ishimoto, A Adachi.

Abstract

A frame-shift tat gene mutant of human immunodeficiency virus type 1 (HIV-1), which showed no detectable trans-activation potential, was constructed in vitro. Upon transfection, this clone directed the synthesis of virus mRNAs, gag proteins and virion-associated reverse transcriptase (RT) at a low level as was observed with the tat mutants of HIV-2 and simian immunodeficiency virus isolated from African green monkey (SIVAGM). Using these mutant viruses, trans-activation efficiency of viral gene expression by tat was compared among HIV-1, HIV-2, and SIVAGM. SIVAGM seemed to be less dependent on tat for RT production than HIV-1 and HIV-2.

Entities: Disease Species

Mesh：

Substances：

Year: 1990 PMID： 1700693 DOI： 10.1007/bf01310753

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

34 in total

1. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein.

Authors: M Green; P M Loewenstein
Journal: Cell Date: 1988-12-23 Impact factor: 41.582

2. Nucleotide sequence of the AIDS virus, LAV.

Authors: S Wain-Hobson; P Sonigo; O Danos; S Cole; M Alizon
Journal: Cell Date: 1985-01 Impact factor: 41.582

3. Transcription of novel open reading frames of AIDS retrovirus during infection of lymphocytes.

Authors: A B Rabson; D F Daugherty; S Venkatesan; K E Boulukos; S I Benn; T M Folks; P Feorino; M A Martin
Journal: Science Date: 1985-09-27 Impact factor: 47.728

4. Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.

Authors: J Sodroski; R Patarca; C Rosen; F Wong-Staal; W Haseltine
Journal: Science Date: 1985-07-05 Impact factor: 47.728

5. The trans-activator gene of HTLV-III is essential for virus replication.

Authors: A G Fisher; M B Feinberg; S F Josephs; M E Harper; L M Marselle; G Reyes; M A Gonda; A Aldovini; C Debouk; R C Gallo
Journal: Nature Date: 1986 Mar 27-Apr 2 Impact factor: 49.962

6. Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III.

Authors: C A Rosen; J G Sodroski; W C Goh; A I Dayton; J Lippke; W A Haseltine
Journal: Nature Date: 1986 Feb 13-19 Impact factor: 49.962

7. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.

Authors: A Adachi; H E Gendelman; S Koenig; T Folks; R Willey; A Rabson; M A Martin
Journal: J Virol Date: 1986-08 Impact factor: 5.103

Comparative studies on tat mutants of three primate lentiviruses.

1. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein.

2. Nucleotide sequence of the AIDS virus, LAV.

3. Transcription of novel open reading frames of AIDS retrovirus during infection of lymphocytes.

4. Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.

5. The trans-activator gene of HTLV-III is essential for virus replication.

6. Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III.

7. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.

8. Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

9. Tat protein from human immunodeficiency virus forms a metal-linked dimer.

10. DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1. Generation and characterization of the human immunodeficiency virus type 1 mutants.

2. Lentivirus vectors using human and simian immunodeficiency virus elements.