Literature DB >> 17005828

Enhanced antiscrapie effect using combination drug treatment.

David A Kocisko1, Byron Caughey, John D Morrey, Richard E Race.   

Abstract

Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.

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Year:  2006        PMID： 17005828      PMCID： PMC1610090          DOI： 10.1128/AAC.00715-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

Review 1.  Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders.

Authors:  Byron Caughey; Peter T Lansbury
Journal:  Annu Rev Neurosci       Date:  2003-04-09       Impact factor: 12.449

2.  A porphyrin increases survival time of mice after intracerebral prion infection.

Authors:  David A Kocisko; Winslow S Caughey; Richard E Race; Grant Roper; Byron Caughey; John D Morrey
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

Review 3.  The statistics of synergism.

Authors:  B K Slinker
Journal:  J Mol Cell Cardiol       Date:  1998-04       Impact factor: 5.000

4.  Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen.

Authors:  R Race; M Oldstone; B Chesebro
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

5.  Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease.

Authors:  N V Todd; J Morrow; K Doh-ura; S Dealler; S O'Hare; P Farling; M Duddy; N G Rainov
Journal:  J Infect       Date:  2005-06       Impact factor: 6.072

Review 6.  Porphyrin-related photosensitizers for cancer imaging and therapeutic applications.

Authors:  K Berg; P K Selbo; A Weyergang; A Dietze; L Prasmickaite; A Bonsted; B Ø Engesaeter; E Angell-Petersen; T Warloe; N Frandsen; A Høgset
Journal:  J Microsc       Date:  2005-05       Impact factor: 1.758

7.  New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products.

Authors:  David A Kocisko; Gerald S Baron; Richard Rubenstein; Jiancao Chen; Salomon Kuizon; Byron Caughey
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

8.  Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models.

Authors:  Katsumi Doh-ura; Kensuke Ishikawa; Ikuko Murakami-Kubo; Kensuke Sasaki; Shirou Mohri; Richard Race; Toru Iwaki
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

9.  Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines.

Authors:  W S Caughey; L D Raymond; M Horiuchi; B Caughey
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-13       Impact factor: 11.205

Review 10.  Prions.

Authors:  S B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205
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  7 in total

Review 1.  Emergence and natural selection of drug-resistant prions.

Authors:  James Shorter
Journal:  Mol Biosyst       Date:  2010-04-27

2.  Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.

Authors:  B Michael Silber; Satish Rao; Kimberly L Fife; Alejandra Gallardo-Godoy; Adam R Renslo; Deepak K Dalvie; Kurt Giles; Yevgeniy Freyman; Manuel Elepano; Joel R Gever; Zhe Li; Matthew P Jacobson; Yong Huang; Leslie Z Benet; Stanley B Prusiner
Journal:  Pharm Res       Date:  2013-02-16       Impact factor: 4.200

3.  Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity.

Authors:  Winslow S Caughey; Suzette A Priola; David A Kocisko; Lynne D Raymond; Anne Ward; Byron Caughey
Journal:  Antimicrob Agents Chemother       Date:  2007-08-20       Impact factor: 5.191

4.  A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.

Authors:  Patricia Spilman; Pierre Lessard; Mamta Sattavat; Clarissa Bush; Thomas Tousseyn; Eric J Huang; Kurt Giles; Todd Golde; Pritam Das; Abdul Fauq; Stanley B Prusiner; Stephen J Dearmond
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-22       Impact factor: 11.205

5.  Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.

Authors:  B Michael Silber; Joel R Gever; Zhe Li; Alejandra Gallardo-Godoy; Adam R Renslo; Kartika Widjaja; John J Irwin; Satish Rao; Matthew P Jacobson; Sina Ghaemmaghami; Stanley B Prusiner
Journal:  Bioorg Med Chem       Date:  2013-09-18       Impact factor: 3.641

6.  NIAID resources for developing new therapies for severe viral infections.

Authors:  Heather Greenstone; Beth Spinelli; Christopher Tseng; Susan Peacock; Katherine Taylor; Catherine Laughlin
Journal:  Antiviral Res       Date:  2007-11-09       Impact factor: 5.970

7.  Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt-Jakob disease.

Authors:  Bradley R Groveman; Natalia C Ferreira; Simote T Foliaki; Ryan O Walters; Clayton W Winkler; Brent Race; Andrew G Hughson; Gianluigi Zanusso; Cathryn L Haigh
Journal:  Sci Rep       Date:  2021-03-09       Impact factor: 4.996
  7 in total

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