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Literature DB >> 16436739

A porphyrin increases survival time of mice after intracerebral prion infection.

David A Kocisko¹, Winslow S Caughey, Richard E Race, Grant Roper, Byron Caughey, John D Morrey.

Abstract

Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2006 PMID： 16436739 PMCID： PMC1366918 DOI： 10.1128/AAC.50.2.759-761.2006

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

12 in total

1. Porphyrin and phthalocyanine antiscrapie compounds.

Authors: S A Priola; A Raines; W S Caughey
Journal: Science Date: 2000-02-25 Impact factor: 47.728

2. Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen.

Authors: R Race; M Oldstone; B Chesebro
Journal: J Virol Date: 2000-01 Impact factor: 5.103

3. Congo red prolongs the incubation period in scrapie-infected hamsters.

Authors: L Ingrosso; A Ladogana; M Pocchiari
Journal: J Virol Date: 1995-01 Impact factor: 5.103

4. Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease.

Authors: N V Todd; J Morrow; K Doh-ura; S Dealler; S O'Hare; P Farling; M Duddy; N G Rainov
Journal: J Infect Date: 2005-06 Impact factor: 6.072

5. Tetracyclines affect prion infectivity.

Authors: Gianluigi Forloni; Selina Iussich; Tazeen Awan; Laura Colombo; Nadia Angeretti; Laura Girola; Ilaria Bertani; Giorgio Poli; Maria Caramelli; Maria Grazia Bruzzone; Laura Farina; Lucia Limido; Giacomina Rossi; Giorgio Giaccone; James W Ironside; Orso Bugiani; Mario Salmona; Fabrizio Tagliavini
Journal: Proc Natl Acad Sci U S A Date: 2002-07-29 Impact factor: 11.205

6. Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice.

Authors: Suzette A Priola; Anne Raines; Winslow Caughey
Journal: J Infect Dis Date: 2003-08-14 Impact factor: 5.226

Review 7. Prion diseases--close to effective therapy?

Authors: Neil R Cashman; Byron Caughey
Journal: Nat Rev Drug Discov Date: 2004-10 Impact factor: 84.694

8. Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines.

Authors: W S Caughey; L D Raymond; M Horiuchi; B Caughey
Journal: Proc Natl Acad Sci U S A Date: 1998-10-13 Impact factor: 11.205

9. Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters.

Authors: M Pocchiari; S Schmittinger; C Masullo
Journal: J Gen Virol Date: 1987-01 Impact factor: 3.891

Review 10. Approaches to prophylaxis and therapy.

Authors: Dominique Dormont
Journal: Br Med Bull Date: 2003 Impact factor: 4.291

16 in total

1. Enhanced antiscrapie effect using combination drug treatment.

Authors: David A Kocisko; Byron Caughey; John D Morrey; Richard E Race
Journal: Antimicrob Agents Chemother Date: 2006-10 Impact factor: 5.191

2. Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prions.

Authors: Chang-Hyun Song; Osamu Honmou; Hidefumi Furuoka; Motohiro Horiuchi
Journal: J Virol Date: 2011-08-03 Impact factor: 5.103

3. Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.

Authors: Fabienne Leidel; Martin Eiden; Markus Geissen; Hans A Kretzschmar; Armin Giese; Thomas Hirschberger; Paul Tavan; Hermann M Schätzl; Martin H Groschup
Journal: Antimicrob Agents Chemother Date: 2011-07-11 Impact factor: 5.191

4. Multimodal small-molecule screening for human prion protein binders.

Authors: Andrew G Reidenbach; Michael F Mesleh; Dominick Casalena; Sonia M Vallabh; Jayme L Dahlin; Alison J Leed; Alix I Chan; Dmitry L Usanov; Jenna B Yehl; Christopher T Lemke; Arthur J Campbell; Rishi N Shah; Om K Shrestha; Joshua R Sacher; Victor L Rangel; Jamie A Moroco; Murugappan Sathappa; Maria Cristina Nonato; Kong T Nguyen; S Kirk Wright; David R Liu; Florence F Wagner; Virendar K Kaushik; Douglas S Auld; Stuart L Schreiber; Eric Vallabh Minikel
Journal: J Biol Chem Date: 2020-07-28 Impact factor: 5.157

5. Prophylactic effect of dietary seaweed Fucoidan against enteral prion infection.

Authors: Katsumi Doh-Ura; Tomoko Kuge; Miyuki Uomoto; Keiko Nishizawa; Yuri Kawasaki; Masahiko Iha
Journal: Antimicrob Agents Chemother Date: 2007-04-16 Impact factor: 5.191

6. meso-Tetra(pentafluorophenyl)porphyrin as an efficient platform for combinatorial synthesis and the selection of new photodynamic therapeutics using a cancer cell line.

Authors: Diana Samaroo; Mikki Vinodu; Xin Chen; Charles Michael Drain
Journal: J Comb Chem Date: 2007-09-15

10. Prion Protein-Hemin Interaction Upregulates Hemoglobin Synthesis: Implications for Cerebral Hemorrhage and Sporadic Creutzfeldt-Jakob Disease.

Authors: Ajai K Tripathi; Neena Singh
Journal: J Alzheimers Dis Date: 2016 Impact factor: 4.472