Literature DB >> 17003873

Dual colour, microarray-based, analysis of 10,000 protease substrates.

Juan J Díaz-Mochón1, Laurent Bialy, Mark Bradley.   

Abstract

A 10,000 member PNA-encoded library of FRET based peptides was synthesised for global analysis of protease cleavage specificity; analysis was achieved using a DNA microarray and consumed minimal quantities of enzyme (60 pmole) and library (3.5 nmole).

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Year:  2006        PMID: 17003873     DOI: 10.1039/b609029j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  3 in total

Review 1.  Deciphering enzyme function using peptide arrays.

Authors:  Alexandra Thiele; Gabriele I Stangl; Mike Schutkowski
Journal:  Mol Biotechnol       Date:  2011-11       Impact factor: 2.695

Review 2.  Fluorescent DNA-based enzyme sensors.

Authors:  Nan Dai; Eric T Kool
Journal:  Chem Soc Rev       Date:  2011-02-02       Impact factor: 54.564

3.  DNA display of PNA-tagged ligands: a versatile strategy to screen libraries and control geometry of multidentate ligands.

Authors:  Nicolas Winssinger
Journal:  Artif DNA PNA XNA       Date:  2012-07-01
  3 in total

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