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Literature DB >> 1700364

The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) can activate a ligand-gated ion channel in Helix neurones.

Abstract

This report presents evidence that the molluscan neuropeptide FMRFamide can directly activate a ligand-gated ion channel in Helix neurones. Using the patch-clamp technique we have observed unitary currents activated by the application of FMRFamide onto outside-out patches. As for the whole-cell response, Na+ ions are the main charge carriers. We conclude that FMRFamide may act as a fast depolarizing neurotransmitter in the Helix nervous system.

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Year: 1990 PMID： 1700364 DOI： 10.1007/bf00382698

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

8 in total

1. Analysis of FMRF-amide effects on Aplysia bursting neurons.

Authors: P Ruben; J W Johnson; S Thompson
Journal: J Neurosci Date: 1986-01 Impact factor: 6.167

2. Nicotinic-type unitary currents in Helix neurons.

Authors: K A Green; A Cadogan; G A Cottrell
Journal: Comp Biochem Physiol A Comp Physiol Date: 1989

3. A histamine-activated chloride channel involved in neurotransmission at a photoreceptor synapse.

Authors: R C Hardie
Journal: Nature Date: 1989-06-29 Impact factor: 49.962

4. Multiple actions of a molluscan cardioexcitatory neuropeptide and related peptides on identified Helix neurones.

Authors: G A Cottrell; N W Davies; K A Green
Journal: J Physiol Date: 1984-11 Impact factor: 5.182

5. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors: O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal: Pflugers Arch Date: 1981-08 Impact factor: 3.657

6. 5-HT3 receptors are membrane ion channels.

Authors: V Derkach; A Surprenant; R A North
Journal: Nature Date: 1989-06-29 Impact factor: 49.962

7. Effect of curare on responses to different putative neurotransmitters in Aplysia neurons.

Authors: D O Carpenter; J W Swann; P J Yarowsky
Journal: J Neurobiol Date: 1977-03

8. Guanosine 5'-triphosphate analogue activates potassium current modulated by neurotransmitters in Aplysia neurones.

Authors: V Brezina
Journal: J Physiol Date: 1988-12 Impact factor: 5.182

8 in total

22 in total

Review 1. Animal-microbe interactions and the evolution of nervous systems.

Authors: Heather L Eisthen; Kevin R Theis
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2016-01-05 Impact factor: 6.237

2. Single-channel currents of a peptide-gated sodium channel expressed in Xenopus oocytes.

Authors: A B Zhainazarov; G A Cottrell
Journal: J Physiol Date: 1998-11-15 Impact factor: 5.182

3. Three homologous subunits form a high affinity peptide-gated ion channel in Hydra.

Authors: Stefan Dürrnagel; Anne Kuhn; Charisios D Tsiairis; Michael Williamson; Hubert Kalbacher; Cornelis J P Grimmelikhuijzen; Thomas W Holstein; Stefan Gründer
Journal: J Biol Chem Date: 2010-02-16 Impact factor: 5.157

4. A review of FMRFamide- and RFamide-like peptides in metazoa.

Authors: Robert J Walker; Sylvana Papaioannou; Lindy Holden-Dye
Journal: Invert Neurosci Date: 2010-02-26

5. Cloning and expression of a FMRFamide-gated Na(+) channel from Helisoma trivolvis and comparison with the native neuronal channel.

Authors: M C Jeziorski; K A Green; J Sommerville; G A Cottrell
Journal: J Physiol Date: 2000-07-01 Impact factor: 5.182