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Literature DB >> 16133260

Molecular cloning and functional characterization of the Aplysia FMRFamide-gated Na+ channel.

Yasuo Furukawa¹, Yoshiyuki Miyawaki, Genbu Abe.

Abstract

FMRFamide-gated Na+ channel (FaNaC) is the only known peptide-gated ion channel, which belongs to the epithelial Na+ channel/degenerin (ENaC/DEG) family. We have cloned a putative FaNaC from the Aplysia kurodai CNS library using PCR, and examined its characteristics in Xenopus oocytes. A. kurodai FaNaC (AkFaNaC) comprised with 653 amino acids, and the sequence predicts two putative membrane domains and a large extracellular domain as in other members of the ENaC/DEG family. In oocytes expressing AkFaNaC, FMRFamide evoked amiloride-sensitive Na+ current. Different from the known FaNaCs (Helix and Helisoma FaNaCs), AkFaNaC was blocked by external Ca2+ but not by Mg2+. Also, desensitization of the current was enhanced by Mg2+ but not by Ca2+. The FMRFamide-gated current was depressed in both low and high pH. These results indicate that AkFaNaC is an FaNaC of Aplysia, and that the channel has Aplysia specific functional domains.

Entities: Chemical Disease Species

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Year: 2005 PMID： 16133260 DOI： 10.1007/s00424-005-1498-z

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

39 in total

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Authors: Stephan Kellenberger; Laurent Schild
Journal: Physiol Rev Date: 2002-07 Impact factor: 37.312

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Authors: A B Zhainazarov; G A Cottrell
Journal: J Physiol Date: 1998-11-15 Impact factor: 5.182

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Journal: J Biol Chem Date: 1998-04-03 Impact factor: 5.157

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Journal: J Biol Chem Date: 1997-08-22 Impact factor: 5.157

5. Cloning and expression of a FMRFamide-gated Na(+) channel from Helisoma trivolvis and comparison with the native neuronal channel.

Authors: M C Jeziorski; K A Green; J Sommerville; G A Cottrell
Journal: J Physiol Date: 2000-07-01 Impact factor: 5.182

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Journal: J Membr Biol Date: 1984 Impact factor: 1.843

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Journal: J Gen Physiol Date: 1997-01 Impact factor: 4.086

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Authors: G A Cottrell
Journal: J Exp Biol Date: 1997-09 Impact factor: 3.312

9. The FMRFamide-related decapeptide of Mytilus contains a D-amino acid residue.

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Journal: Comp Biochem Physiol C Date: 1992-05

10. The brain of Lymnaea contains a family of FMRFamide-like peptides.

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Journal: Peptides Date: 1987 May-Jun Impact factor: 3.750

13 in total

1. Exploration of the Peptide Recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel.

Authors: You-Ya Niu; Yang Yang; Yan Liu; Li-Dong Huang; Xiao-Na Yang; Ying-Zhe Fan; Xiao-Yang Cheng; Peng Cao; You-Min Hu; Lingyong Li; Xiang-Yang Lu; Yun Tian; Ye Yu
Journal: J Biol Chem Date: 2016-02-11 Impact factor: 5.157

2. Heterologous expression of the invertebrate FMRFamide-gated sodium channel as a mechanism to selectively activate mammalian neurons.

Authors: S M Schanuel; K A Bell; S C Henderson; A R McQuiston
Journal: Neuroscience Date: 2008-06-10 Impact factor: 3.590

3. Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain.

Authors: Catharina Reimers; Cheng-Han Lee; Hubert Kalbacher; Yuemin Tian; Chih-Hsien Hung; Axel Schmidt; Lea Prokop; Silke Kauferstein; Dietrich Mebs; Chih-Cheng Chen; Stefan Gründer
Journal: Proc Natl Acad Sci U S A Date: 2017-04-10 Impact factor: 11.205

4. Electrostatic charge at position 552 affects the activation and permeation of FMRFamide-gated Na+ channels.

Authors: Yu Kodani; Yasuo Furukawa
Journal: J Physiol Sci Date: 2014-01-12 Impact factor: 2.781

5. The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide.

Authors: Xiao-Na Yang; You-Ya Niu; Yan Liu; Yang Yang; Jin Wang; Xiao-Yang Cheng; Hong Liang; Heng-Shan Wang; You-Min Hu; Xiang-Yang Lu; Michael X Zhu; Tian-Le Xu; Yun Tian; Ye Yu
Journal: J Biol Chem Date: 2017-11-09 Impact factor: 5.157

Review 6. Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.

Authors: Israel Hanukoglu; Aaron Hanukoglu
Journal: Gene Date: 2016-01-07 Impact factor: 3.688