Literature DB >> 17003126

FLASH is an essential component of Cajal bodies.

D Barcaroli1, D Dinsdale, M H Neale, L Bongiorno-Borbone, M Ranalli, E Munarriz, A E Sayan, J M McWilliam, T M Smith, E Fava, R A Knight, G Melino, V De Laurenzi.   

Abstract

Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as a component of the apoptosis signaling pathway, is mainly localized in Cajal bodies and is essential for their structure. Reduction in FLASH expression by short hairpin RNA results in disruption of the normal architecture of the Cajal body and relocalization of its components. Because the function of FLASH in the apoptosis receptor signaling pathway has been strongly questioned, we have now identified a clear function for this protein.

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Year:  2006        PMID： 17003126      PMCID： PMC1578500          DOI： 10.1073/pnas.0604225103

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  Apoptosis. Searching for FLASH domains.

Authors:  E V Koonin; L Aravind; K Hofmann; J Tschopp; V M Dixit
Journal:  Nature       Date:  1999-10-14       Impact factor: 49.962

Review 2.  Cajal bodies: the first 100 years.

Authors:  J G Gall
Journal:  Annu Rev Cell Dev Biol       Date:  2000       Impact factor: 13.827

Review 3.  The role of PML in tumor suppression.

Authors:  Paolo Salomoni; Pier Paolo Pandolfi
Journal:  Cell       Date:  2002-01-25       Impact factor: 41.582

4.  FLASH coordinates NF-kappa B activity via TRAF2.

Authors:  Y H Choi; K B Kim; H H Kim; G S Hong; Y K Kwon; C W Chung; Y M Park; Z J Shen; B J Kim; S Y Lee; Y K Jung
Journal:  J Biol Chem       Date:  2001-05-04       Impact factor: 5.157

5.  Morphological assessment of apoptosis in human lung cells.

Authors:  Lori D Dwyer-Nield; David Dinsdale; J John Cohen; Margaret K T Squier; Alvin M Malkinson
Journal:  Methods Mol Med       Date:  2003

6.  Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.

Authors:  T Ma; B A Van Tine; Y Wei; M D Garrett; D Nelson; P D Adams; J Wang; J Qin; L T Chow; J W Harper
Journal:  Genes Dev       Date:  2000-09-15       Impact factor: 11.361

7.  Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators.

Authors:  Tomoshige Kino; George P Chrousos
Journal:  J Biol Chem       Date:  2002-12-10       Impact factor: 5.157

8.  FLASH is required for histone transcription and S-phase progression.

Authors:  D Barcaroli; L Bongiorno-Borbone; A Terrinoni; T G Hofmann; M Rossi; R A Knight; A G Matera; G Melino; V De Laurenzi
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-26       Impact factor: 11.205

Review 9.  Cajal bodies and coilin--moving towards function.

Authors:  Stephen C Ogg; Angus I Lamond
Journal:  J Cell Biol       Date:  2002-10-14       Impact factor: 10.539

10.  Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product.

Authors:  K E Tucker; M T Berciano; E Y Jacobs; D F LePage; K B Shpargel; J J Rossire; E K Chan; M Lafarga; R A Conlon; A G Matera
Journal:  J Cell Biol       Date:  2001-07-23       Impact factor: 10.539
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  32 in total

1.  Depletion of hCINAP by RNA interference causes defects in Cajal body formation, histone transcription, and cell viability.

Authors:  Jinfang Zhang; Feiyun Zhang; Xiaofeng Zheng
Journal:  Cell Mol Life Sci       Date:  2010-02-26       Impact factor: 9.261

2.  Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability.

Authors:  Yujing Li; Ka-Wing Fong; Mengfan Tang; Xin Han; Zihua Gong; Wenbin Ma; Michael Hebert; Zhou Songyang; Junjie Chen
Journal:  J Cell Sci       Date:  2014-02-25       Impact factor: 5.285

Review 3.  Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body.

Authors:  Robert J Duronio; William F Marzluff
Journal:  RNA Biol       Date:  2017-01-06       Impact factor: 4.652

4.  CD19-positive antibody-secreting cells provide immune memory.

Authors:  C J Groves; J Carrell; R Grady; B Rajan; C A Morehouse; R Halpin; J Wang; J Wu; Y Shrestha; R Rayanki; R Kolbeck; Y Wang; R Herbst
Journal:  Blood Adv       Date:  2018-11-27

Review 5.  Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export.

Authors:  Keiichi Izumikawa; Hideaki Ishikawa; Richard J Simpson; Nobuhiro Takahashi
Journal:  RNA Biol       Date:  2018-05-11       Impact factor: 4.652

6.  FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies.

Authors:  Kristijana Milovic-Holm; Eva Krieghoff; Kirsten Jensen; Hans Will; Thomas G Hofmann
Journal:  EMBO J       Date:  2007-01-24       Impact factor: 11.598

Review 7.  The Cajal body and the nucleolus: "In a relationship" or "It's complicated"?

Authors:  Laura Trinkle-Mulcahy; Judith E Sleeman
Journal:  RNA Biol       Date:  2016-09-23       Impact factor: 4.652

8.  Regulated specific proteolysis of the Cajal body marker protein coilin.

Authors:  Venkatramreddy Velma; Hanna J Broome; Michael D Hebert
Journal:  Chromosoma       Date:  2012-10-14       Impact factor: 4.316

9.  SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2.

Authors:  Astrid Vennemann; Thomas G Hofmann
Journal:  Cell Cycle       Date:  2013-05-13       Impact factor: 4.534

10.  Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos.

Authors:  Prachi N Ghule; Rong-Lin Xie; Jennifer L Colby; Jaime A Rivera-Pérez; Stephen N Jones; Jane B Lian; Janet L Stein; Andre J van Wijnen; Gary S Stein
Journal:  Dev Biol       Date:  2016-09-05       Impact factor: 3.582
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